Animal models of closed-skull, repetitive mild traumatic brain injury

WS Hoogenboom, CA Branch, ML Lipton - Pharmacology & therapeutics, 2019 - Elsevier
The underlying mechanisms that result in neurophysiological changes and cognitive
sequelae in the context of repetitive mild traumatic brain injury (rmTBI) remain poorly …

[HTML][HTML] Long-term cognitive impairments and pathological alterations in a mouse model of repetitive mild traumatic brain injury

J Luo, A Nguyen, S Villeda, H Zhang, Z Ding… - Frontiers in …, 2014 - frontiersin.org
Mild traumatic brain injury (mTBI, also referred to as concussion) accounts for the majority of
all traumatic brain injuries. The consequences of repetitive mTBI have become of particular …

Lifelong behavioral and neuropathological consequences of repetitive mild traumatic brain injury

BC Mouzon, C Bachmeier, JO Ojo… - Annals of clinical …, 2018 - Wiley Online Library
Objective Exposure to repetitive concussion, or mild traumatic brain injury (mTBI), has been
linked with increased risk of long‐term neurodegenerative changes, specifically chronic …

Adolescent mice demonstrate a distinct pattern of injury after repetitive mild traumatic brain injury

R Mannix, J Berkner, Z Mei, S Alcon… - Journal of …, 2017 - liebertpub.com
Recently, there has been increasing interest in outcomes after repetitive mild traumatic brain
injury (rmTBI)(eg, sports concussions). Although most of the scientific attention has focused …

Greater neurobehavioral deficits occur in adult mice after repeated, as compared to single, mild traumatic brain injury (mTBI)

JN Nichols, AS Deshane, TL Niedzielko… - Behavioural brain …, 2016 - Elsevier
Mild traumatic brain injury (mTBI) accounts for the majority of all brain injuries and affected
individuals typically experience some extent of cognitive and/or neuropsychiatric deficits …

Functional and molecular correlates after single and repeated rat closed-head concussion: indices of vulnerability after brain injury

A Mountney, AM Boutté, CM Cartagena… - Journal of …, 2017 - liebertpub.com
Closed-head concussive injury is one of the most common causes of traumatic brain injury
(TBI). Isolated concussions frequently produce acute neurological impairments, and …

The potential for animal models to provide insight into mild traumatic brain injury: translational challenges and strategies

SR Shultz, SJ McDonald, CV Haar, A Meconi… - Neuroscience & …, 2017 - Elsevier
Mild traumatic brain injury (mTBI) is a common health problem. There is tremendous
variability and heterogeneity in human mTBI, including mechanisms of injury, biomechanical …

[HTML][HTML] Short and long term behavioral and pathological changes in a novel rodent model of repetitive mild traumatic brain injury

KM McAteer, F Corrigan, E Thornton, RJ Turner… - PLoS …, 2016 - journals.plos.org
A history of concussion, particularly repeated injury, has been linked to an increased risk for
the development of neurodegenerative diseases, particularly chronic traumatic …

Modeling the pathobiology of repetitive traumatic brain injury in immortalized neuronal cell lines

MJ Kane, H Hatic, V Delic, JS Dennis, CL Butler… - Brain research, 2011 - Elsevier
Repetitive mild traumatic brain injury (mTBI) represents a major public health problem. Many
individuals who suffer repetitive mTBIs suffer from Post-Concussion Syndrome, a …

Chronic neuropathological and neurobehavioral changes in a repetitive mild traumatic brain injury model

BC Mouzon, C Bachmeier, A Ferro, JO Ojo… - Annals of …, 2014 - Wiley Online Library
Objective Traumatic brain injury (TBI) is a recognized risk factor for later development of
neurodegenerative disease. However, the mechanisms contributing to neurodegeneration …