The four-year journey abroad in pursuing a Dr. rer. nat. has been incredibly enriching on
both academic and personal fronts. It would not have been possible without the support and …

Chemical synthesis or semi‐synthesis of membrane proteins can provide unique molecular
tools, such as site‐specific isotope labeling or post‐translationally modified membrane …

Naturally occurring peptides with high membrane permeability often have ester bonds on
their backbones. However, the impact of amide-to-ester substitutions on the membrane …

Membranes consisting of phospholipid bilayers are an essential constituent of eukaryotic
cells and their compartments. The alteration of their composition, structure, and morphology …

Rational design and engineering of membrane-active peptides remains a largely unsatisfied
goal. We have hypothesized that this is due, in part, to the fact that some membrane …

Chemical synthesis can produce membrane proteins bearing specifically designed
modifications (eg, phosphorylation, isotope labeling) that are difficult to obtain through …

Biomembranes are important targets in molecular design. Our laboratory has been exploring
the design of functional peptides that modulate membrane barrier function, lipid packing …

Membrane active peptides (MAPs) have gained wide interest due to their far reaching
applications in drug discovery and drug delivery. The search for new MAPs, however, has …

Previously we introduced peptidiscs as an alternative to detergents to stabilize membrane
proteins in solution (Carlson et al., 2018). Here, we present 'on-gradient'reconstitution, a …

Membrane proteins are involved in all cellular processes from signaling cascades to nutrient
uptake and waste disposal. Because of these essential functions, many membrane proteins …