[HTML][HTML] Positive feedback regulation between glycolysis and histone lactylation drives oncogenesis in pancreatic ductal adenocarcinoma
F Li, W Si, L Xia, D Yin, T Wei, M Tao, X Cui, J Yang… - Molecular Cancer, 2024 - Springer
Background Metabolic reprogramming and epigenetic alterations contribute to the
aggressiveness of pancreatic ductal adenocarcinoma (PDAC). Lactate-dependent histone …
aggressiveness of pancreatic ductal adenocarcinoma (PDAC). Lactate-dependent histone …
[HTML][HTML] Histone Lactylation Dynamics: Unlocking the Triad of Metabolism, Epigenetics, and Immune Regulation in Metastatic Cascade of Pancreatic Cancer
X Wang, X Liu, R Xiao, Y Fang, F Zhou, M Gu, X Luo… - Cancer Letters, 2024 - Elsevier
Cancer cells rewire metabolism to sculpt the immune tumor microenvironment (TME) and
propel tumor advancement, which intricately tied to post-translational modifications. Histone …
propel tumor advancement, which intricately tied to post-translational modifications. Histone …
[HTML][HTML] Novel lactylation-related signature to predict prognosis for pancreatic adenocarcinoma
T Peng, F Sun, JC Yang, MH Cai, MX Huai… - World Journal of …, 2024 - ncbi.nlm.nih.gov
BACKGROUND Lactate, previously considered a metabolic byproduct, is pivotal in cancer
progression and maintaining the immunosuppressive tumor microenvironment. Further …
progression and maintaining the immunosuppressive tumor microenvironment. Further …
[HTML][HTML] Transcriptional, chromatin, and metabolic landscapes of LDHA inhibitor–resistant pancreatic ductal adenocarcinoma
Metabolic reprogramming, due in part to the overexpression of metabolic enzymes, is a key
hallmark of cancer cells. Lactate dehydrogenase (LDHA), a metabolic enzyme that catalyzes …
hallmark of cancer cells. Lactate dehydrogenase (LDHA), a metabolic enzyme that catalyzes …
Functional inhibition of lactate dehydrogenase suppresses pancreatic adenocarcinoma progression
C Cheng, HY Tan, N Wang, L Chen… - Clinical and …, 2021 - Wiley Online Library
Background Pancreatic adenocarcinoma (PAAD) a highly lethal malignancy. The current
use of clinical parameters may not accurately predict the clinical outcome, which further …
use of clinical parameters may not accurately predict the clinical outcome, which further …
[HTML][HTML] Aberrant lactate dehydrogenase A signaling contributes metabolic signatures in pancreatic cancer
W Jiang, L Qiao, D Zuo, D Qin, J Xiao… - Annals of …, 2021 - ncbi.nlm.nih.gov
Background Pancreatic cancer (PC) has the lowest 5-year survival rate; therefore, new early
screening methods and therapeutic targets are still urgently required. Emerging …
screening methods and therapeutic targets are still urgently required. Emerging …
[HTML][HTML] LIPH contributes to glycolytic phenotype in pancreatic ductal adenocarcinoma by activating LPA/LPAR axis and maintaining ALDOA stability
L Han, Y Jiang, M Shi, L Gan, Z Wu, M Xue… - Journal of Translational …, 2023 - Springer
Background LIPH, a membrane-associated phosphatidic acid-selective phospholipase A1a,
can produce LPA (Lysophosphatidic acid) from PA (Phosphatidic acid) on the outer leaflet of …
can produce LPA (Lysophosphatidic acid) from PA (Phosphatidic acid) on the outer leaflet of …
Hyperglycaemia induces metabolic reprogramming into a glycolytic phenotype and promotes epithelial-mesenchymal transitions via YAP/TAZ-Hedgehog signalling …
Z Liu, H Hayashi, K Matsumura, Y Ogata… - British Journal of …, 2023 - nature.com
Background Hyperglycaemia is a well-known initial symptom in patients with pancreatic
ductal adenocarcinoma (PDAC). Metabolic reprogramming in cancer, described as the …
ductal adenocarcinoma (PDAC). Metabolic reprogramming in cancer, described as the …
[HTML][HTML] LINC00842 inactivates transcription co-regulator PGC-1α to promote pancreatic cancer malignancy through metabolic remodelling
The molecular mechanism underlying pancreatic ductal adenocarcinoma (PDAC)
malignancy remains unclear. Here, we characterize a long intergenic non-coding RNA …
malignancy remains unclear. Here, we characterize a long intergenic non-coding RNA …
Palmitoylation alters LDHA activity and pancreatic cancer response to chemotherapy
Lactate dehydrogenase A (LDHA) serves as a key regulator of the Warburg Effect by
catalyzing the conversion of pyruvate to lactate in the final step of glycolysis. Both the …
catalyzing the conversion of pyruvate to lactate in the final step of glycolysis. Both the …