Acquired genetic or cytogenetic alterations in a blood stem cell that confer clonal fitness
promote its relative expansion leading to clonal hematopoiesis (CH). Despite a largely intact …

Clonal hematopoiesis (CH) occurs in hematopoietic stem cells with increased risks of
progressing to hematologic malignancies. CH mutations are predominantly found in aged …

Somatic mutations in hematopoietic stem cells are common with aging and can result in
expansion of clones harboring mutations, termed clonal hematopoiesis. This results in an …

Clonal hematopoiesis (CH) is described as the outsized contribution of expanded clones of
hematopoietic stem and progenitor cells (HSPCs) to blood cell production. The prevalence …

Clonal expansions of mutated hematopoietic cells, termed clonal hematopoiesis, are
common in aging humans. One expected consequence of mutation-associated clonal …

Clonal hematopoiesis (CH) of indeterminate potential (CHIP)/age-related CH is a new
phenomenon of aging that affects a large proportion (> 10%) of older adults. CH arises upon …

Clonal hematopoiesis (CH) of indeterminate potential (CHIP), defined as the presence of a
somatic mutation in the peripheral blood at a variant allele frequency (VAF)≥ 2%, affects at …

Age-related diseases are frequently linked to pathological immune dysfunction, including
excessive inflammation, autoreactivity and immunodeficiency. Recent analyses of human …

Somatic or acquired mutations are postzygotic genetic variations that can occur within any
tissue. These mutations accumulate during aging and have classically been linked to …

Highlights•Environmental factors influence the development of clonal hematopoiesis.•
Inflammation exerts a strong influence on hematopoietic stem cell biology and may serve as …