Synthesis and modifications of carbohydrates, using biotransformations
AM Daines, BA Maltman, SL Flitsch - Current Opinion in Chemical Biology, 2004 - Elsevier
Enzymes continue to be used as important catalysts, for the generation of rare and
'unnatural'monosaccharides and for the selective formation of glycosidic linkages. Multi …
'unnatural'monosaccharides and for the selective formation of glycosidic linkages. Multi …
Glycosyltransferases as biocatalysts
MM Palcic - Current Opinion in Chemical Biology, 2011 - Elsevier
Glycosyltransferases are useful synthetic tools for the preparation of natural
oligosaccharides, glycoconjugates and their analogues. High expression levels of …
oligosaccharides, glycoconjugates and their analogues. High expression levels of …
New approaches to enzymatic glycoside synthesis through directed evolution
R Kittl, SG Withers - Carbohydrate research, 2010 - Elsevier
The expanding field of glycobiology requires tools for the synthesis of structurally defined
oligosaccharides and glycoconjugates, while any potential therapeutic applications of sugar …
oligosaccharides and glycoconjugates, while any potential therapeutic applications of sugar …
Teaching old enzymes new tricks: engineering and evolution of glycosidases and glycosyl transferases for improved glycoside synthesis
FA Shaikh, SG Withers - Biochemistry and Cell Biology, 2008 - cdnsciencepub.com
The therapeutic potential of glycosides has made them an attractive target for drug
development. The biological extraction and chemical synthesis of these molecules is often …
development. The biological extraction and chemical synthesis of these molecules is often …
Recent biotechnological progress in enzymatic synthesis of glycosides
Glycosylation is one of the most important post-modification processes of small molecules
and enables the parent molecule to have increased solubility, stability, and bioactivity …
and enables the parent molecule to have increased solubility, stability, and bioactivity …
Large-scale synthesis of carbohydrates for pharmaceutical development
J Zhang, B Wu, Z Liu, P Kowal, X Chen… - Current Organic …, 2001 - ingentaconnect.com
The field of glycobiology has recently enjoyed an enormous expansion boosted by new
discoveries of the critical functions that carbohydrates play in nature. Further research in this …
discoveries of the critical functions that carbohydrates play in nature. Further research in this …
Reprint of: Advanced glycosidases as ingenious biosynthetic instruments
Z Mészáros, P Nekvasilová, P Bojarová, V Křen… - Biotechnology …, 2021 - Elsevier
Until recently, glycosidases, naturally hydrolyzing carbohydrate-active enzymes, have found
few synthetic applications in industry, being primarily used for cleaving unwanted …
few synthetic applications in industry, being primarily used for cleaving unwanted …
Synthesis of glycosides by glycosynthases
MR Hayes, J Pietruszka - Molecules, 2017 - mdpi.com
The many advances in glycoscience have more and more brought to light the crucial role of
glycosides and glycoconjugates in biological processes. Their major influence on the …
glycosides and glycoconjugates in biological processes. Their major influence on the …
Strategies for chemoenzymatic synthesis of carbohydrates
Carbohydrates are structurally complex but functionally important biomolecules. Therefore,
they have been challenging but attractive synthetic targets. While substantial progress has …
they have been challenging but attractive synthetic targets. While substantial progress has …
Systematic screening of synthetic gene-encoded enzymes for synthesis of modified glycosides
Z Armstrong, F Liu, HM Chen, SJ Hallam… - Acs Catalysis, 2019 - ACS Publications
The construction of large, phylogenetically diverse libraries of synthetic genes from a
sequence-based family allows rapid evaluation of the substrate specificity encoded within …
sequence-based family allows rapid evaluation of the substrate specificity encoded within …