Primary immunodeficiency diseases (PID) are a genetically heterogenous group of> 150
disorders that affect distinct components of the innate and adaptive immune system and are …

The paradoxical relationship between immunodeficiency (under-responsiveness) and
autoimmunity (over-responsiveness) affecting the immune system was debated at the Fourth …

Autoimmunity has long been known to be a part of the presenting symptoms and clinical
course of many primary immunodeficiencies. This review will provide an overview of the new …

Primary immunodeficiency diseases (PID s) consist of a genetically heterogeneous group of
immune disorders that affect distinct elements of the immune system. PID patients are more …

Until now we have been “grasping at straws” in our efforts to develop therapeutic
approaches to autoimmune diseases. Such efforts, it is suggested, have been hampered by …

This review identifies critical mechanisms important to conceptualize the association of
primary immune deficiencies and autoimmunity. It highlights a growing appreciation of the …

The recent progress in the genetic characterization of many primary immunodeficiencies
(PIDs) allows for a better understanding of immune molecular and cellular mechanisms. The …

Abstract Background Primary Immunodeficiencies (PIDs) represent unique opportunities to
understand the operation of the human immune system. Accordingly, PIDs associated with …

The primary immunodeficiency diseases (PIDs) include many genetic disorders that affect
different components of the innate and adaptive responses. The number of distinct genetic …

Human primary immunodeficiency diseases are experiments of nature characterized by an
increased susceptibility to infection. In many cases, they are also associated with …