[HTML][HTML] Mosaic Chromosomal Alterations Are Associated With Increased Lung Cancer Risk: Insight From the INTEGRAL-ILCCO Cohort Analysis

C Cheng, W Hong, Y Li, X Xiao, J McKay, Y Han… - Journal of Thoracic …, 2023 - Elsevier
Introduction Mosaic chromosomal alterations (mCAs) detected in white blood cells represent
a type of clonal hematopoiesis (CH) that is understudied compared with CH-related somatic …

Interplay between mosaic chromosomal alterations and polygenic risk score increases risk of non-small cell lung cancer

N Qin, C Chen, L Yang, S Liu, Y Xie, X Xu, J Zhou… - medRxiv, 2022 - medrxiv.org
We investigated autosomal mosaic chromosomal alterations (mCAs) in 10,248 non-small
cell lung cancer (NSCLC) cases and 9,298 cancer-free controls of Chinese ancestry. Mosaic …

Association of the interaction between mosaic chromosomal alterations and polygenic risk score with the risk of lung cancer: an array-based case-control association …

N Qin, C Wang, C Chen, L Yang, S Liu, J Xiang… - The Lancet …, 2022 - thelancet.com
Background Mosaic chromosomal alterations (mCAs) detected from blood-derived DNA are
large structural alterations of clonal haematopoietic origin and are associated with various …

INTEGRAL‐ILCCO cohort data analysis revealed the association of clonal haematopoiesis with an increased risk of lung cancer

C Cheng, W Hong, CI Amos - Clinical and Translational …, 2024 - Wiley Online Library
To investigate the association between clonal haematopoiesis (CH) and lung cancer risk,
we identified CH mutations in 1 059 lung cancer cases and 899 controls using the blood …

Clonal hematopoiesis mutations in patients with lung cancer are associated with lung cancer risk factors

W Hong, A Li, Y Liu, X Xiao, DC Christiani, RJ Hung… - Cancer research, 2022 - AACR
Clonal hematopoiesis (CH) is a phenomenon caused by expansion of white blood cells
descended from a single hematopoietic stem cell. While CH can be associated with …

Genetics of smoking and risk of clonal hematopoiesis

MG Levin, T Nakao, SM Zekavat, S Koyama, AG Bick… - Scientific Reports, 2022 - nature.com
Clonal hematopoiesis of indeterminate potential (CHIP) and mosaic chromosomal
alterations (mCAs) represent two forms of clonal hematopoiesis where clones bearing …

[HTML][HTML] Association of mosaic loss of chromosome Y with lung cancer risk and prognosis in a Chinese population

N Qin, N Li, C Wang, Z Pu, Z Ma, G Jin, M Zhu… - Journal of Thoracic …, 2019 - Elsevier
Introduction Mosaic loss of chromosome Y (mLOY) is the most commonly detectable mosaic
chromosomal event in cancers; however, its underlying relationship with tumorigenesis is …

Clonal hematopoiesis and risk of incident lung cancer

R Tian, B Wiley, J Liu, X Zong, B Truong… - Journal of Clinical …, 2023 - ascopubs.org
PURPOSE To prospectively examine the association between clonal hematopoiesis (CH)
and subsequent risk of lung cancer. METHODS Among 200,629 UK Biobank (UKBB) …

821P Circulating chromosomal alterations in lymphoid malignancies

R Griffin, NJ Boddicker, EG Franke… - Annals of …, 2024 - annalsofoncology.org
Background Mosaic chromosomal alterations (mCAs) are a promising biomarker for
lymphoid malignancies (LMs). mCAs represent a form of clonal hematopoiesis …

Association of clonal hematopoiesis and mosaic chromosomal alterations with solid malignancy incidence and mortality

P Desai, Y Zhou, J Grenet, SK Handelman… - Cancer, 2024 - Wiley Online Library
Background Understanding the impact of clonal hematopoiesis of indeterminate potential
(CHIP) and mosaic chromosomal alterations (mCAs) on solid tumor risk and mortality can …