Depression in neurodegenerative diseases: Common mechanisms and current treatment options

CPC Galts, LEB Bettio, DC Jewett, CC Yang… - Neuroscience & …, 2019 - Elsevier
Major depressive disorder (MDD) is a highly prevalent psychiatric disorder and a major
cause of disability worldwide. This neurological condition is commonly associated with …

The putative neurodegenerative links between depression and Alzheimer's disease

S Wuwongse, RCC Chang, ACK Law - Progress in Neurobiology, 2010 - Elsevier
Alzheimer's disease (AD) is the leading neurodegenerative cause of dementia in the elderly.
Thus far, there is no curative treatment for this devastating condition, thereby creating …

[HTML][HTML] Similarities between depression and neurodegenerative diseases: pathophysiology, challenges in diagnosis and treatment options

M Hussain, P Kumar, S Khan, DK Gordon, S Khan - Cureus, 2020 - ncbi.nlm.nih.gov
Depressive disorder and neurodegenerative diseases are two different clinical entities.
Depression is a common psychiatric disorder in the general population. However, when …

Neurobiology of depression in Parkinson's disease: Insights into epidemiology, molecular mechanisms and treatment strategies

MH Ahmad, MA Rizvi, M Ali, AC Mondal - Ageing research reviews, 2023 - Elsevier
Parkinson's disease (PD) is characterized mainly by motor dysfunctions due to the
progressive loss of dopaminergic neurons. However, PD patients experience a multitude of …

A common challenge in older adults: Classification, overlap, and therapy of depression and dementia

T Leyhe, CF Reynolds III, T Melcher, C Linnemann… - Alzheimer's & …, 2017 - Elsevier
Late-life depression is frequently associated with cognitive impairment. Depressive
symptoms are often associated with or even precede a dementia syndrome. Moreover …

Stuck in a rut: rethinking depression and its treatment

PE Holtzheimer, HS Mayberg - Trends in neurosciences, 2011 - cell.com
The current definition of major depressive disorder (MDD) emerged from efforts to create
reliable diagnostic criteria for clinical and research use. However, despite decades of …

[HTML][HTML] Is dysregulation of the HPA-axis a core pathophysiology mediating co-morbid depression in neurodegenerative diseases?

X Du, TY Pang - Frontiers in psychiatry, 2015 - frontiersin.org
There is increasing evidence of prodromal manifestation of neuropsychiatric symptoms in a
variety of neurodegenerative diseases such as Parkinson's disease (PD) and Huntington's …

[HTML][HTML] Mechanisms underlying neurocognitive dysfunctions in recurrent major depression

P Gałecki, M Talarowska, G Anderson… - … medical journal of …, 2015 - ncbi.nlm.nih.gov
Recent work shows that depression is intimately associated with changes in cognitive
functioning, including memory, attention, verbal fluency, and other aspects of higher-order …

Cognitive dysfunction in depression–pathophysiology and novel targets

AF Carvalho, KK Miskowiak… - CNS & Neurological …, 2014 - ingentaconnect.com
Major depressive disorder (MDD) is associated with cognitive dysfunction encompassing
several domains, including memory, executive function, processing speed and attention …

[HTML][HTML] The pathobiological basis of depression in Parkinson disease: challenges and outlooks

KA Jellinger - Journal of neural transmission, 2022 - Springer
Depression, with an estimated prevalence of about 40% is a most common neuropsychiatric
disorder in Parkinson disease (PD), with a negative impact on quality of life, cognitive …