Regulation of cardiovascular development by adenosine and adenosine-mediated embryo protection
SA Rivkees, CC Wendler - Arteriosclerosis, thrombosis, and …, 2012 - Am Heart Assoc
Few signaling molecules have as much potential to influence the developing mammal as the
nucleoside adenosine. Adenosine levels increase rapidly with tissue hypoxia and …
nucleoside adenosine. Adenosine levels increase rapidly with tissue hypoxia and …
Identification of the heart as the critical site of adenosine mediated embryo protection
CC Wendler, RR Poulsen, S Ghatpande… - BMC developmental …, 2010 - Springer
Background Our understanding of the mechanisms that protect the developing embryo from
intrauterine stress is limited. Recently, adenosine has been demonstrated to play a critical …
intrauterine stress is limited. Recently, adenosine has been demonstrated to play a critical …
Long-term consequences of disrupting adenosine signaling during embryonic development
SA Rivkees, CC Wendler - Molecular aspects of medicine, 2017 - Elsevier
There is growing evidence that disruption in the prenatal environment can have long-lasting
effects on an individual's health in adulthood. Research on the fetal programming of adult …
effects on an individual's health in adulthood. Research on the fetal programming of adult …
A1 adenosine receptors play an essential role in protecting the embryo against hypoxia
CC Wendler, S Amatya, C McClaskey… - Proceedings of the …, 2007 - National Acad Sciences
Embryos can be exposed to environmental factors that induce hypoxia. Currently, our
understanding of the effects of hypoxia on early mammalian development is modest …
understanding of the effects of hypoxia on early mammalian development is modest …
Caffeine acts via A1 adenosine receptors to disrupt embryonic cardiac function
DL Buscariollo, GA Breuer, CC Wendler, SA Rivkees - PLoS One, 2011 - journals.plos.org
Background Evidence suggests that adenosine acts via cardiac A1 adenosine receptors
(A1ARs) to protect embryos against hypoxia. During embryogenesis, A1ARs are the …
(A1ARs) to protect embryos against hypoxia. During embryogenesis, A1ARs are the …
Influences of adenosine on the fetus and newborn
SA Rivkees, Z Zhao, G Porter, C Turner - Molecular genetics and …, 2001 - Elsevier
Few signaling molecules have the potential to influence the developing mammal as the
nucleoside adenosine. In contrast to most neurotransmitters, adenosine is released by all …
nucleoside adenosine. In contrast to most neurotransmitters, adenosine is released by all …
Hypoxia induces cardiac malformations via A1 adenosine receptor activation in chicken embryos
SK Ghatpande, CJ Billington Jr… - … Research Part A …, 2008 - Wiley Online Library
BACKGROUND: The current understanding of the effects of hypoxia on early
embryogenesis is limited. Potential mediators of hypoxic effects include adenosine, which …
embryogenesis is limited. Potential mediators of hypoxic effects include adenosine, which …
Inhibition of cell proliferation in the embryonic myocardium by A1 adenosine receptor activation
Z Zhao, SA Rivkees - … dynamics: an official publication of the …, 2001 - Wiley Online Library
A1 adenosine receptors (A1ARs) are expressed in the embryonic heart and influence
cardiac function at early developmental stages. To test if A1ARs also affect cardiac structural …
cardiac function at early developmental stages. To test if A1ARs also affect cardiac structural …
A1 adenosine receptors potently regulate heart rate in mammalian embryos
A1adenosine receptors (A1ARs) have been recently shown to be expressed in rodent
embryonic hearts at very early stages of development. To determine the functional …
embryonic hearts at very early stages of development. To determine the functional …
Adverse and protective influences of adenosine on the newborn and embryo: implications for preterm white matter injury and embryo protection
SA Rivkees, CC Wendler - Pediatric research, 2011 - nature.com
Few signaling molecules have the potential to influence the developing mammal as the
nucleoside adenosine. Adenosine levels increase rapidly with tissue hypoxia and …
nucleoside adenosine. Adenosine levels increase rapidly with tissue hypoxia and …