Few signaling molecules have as much potential to influence the developing mammal as the
nucleoside adenosine. Adenosine levels increase rapidly with tissue hypoxia and …

Background Our understanding of the mechanisms that protect the developing embryo from
intrauterine stress is limited. Recently, adenosine has been demonstrated to play a critical …

There is growing evidence that disruption in the prenatal environment can have long-lasting
effects on an individual's health in adulthood. Research on the fetal programming of adult …

Embryos can be exposed to environmental factors that induce hypoxia. Currently, our
understanding of the effects of hypoxia on early mammalian development is modest …

Background Evidence suggests that adenosine acts via cardiac A1 adenosine receptors
(A1ARs) to protect embryos against hypoxia. During embryogenesis, A1ARs are the …

Few signaling molecules have the potential to influence the developing mammal as the
nucleoside adenosine. In contrast to most neurotransmitters, adenosine is released by all …

BACKGROUND: The current understanding of the effects of hypoxia on early
embryogenesis is limited. Potential mediators of hypoxic effects include adenosine, which …

A1 adenosine receptors (A1ARs) are expressed in the embryonic heart and influence
cardiac function at early developmental stages. To test if A1ARs also affect cardiac structural …

A1adenosine receptors (A1ARs) have been recently shown to be expressed in rodent
embryonic hearts at very early stages of development. To determine the functional …

Few signaling molecules have the potential to influence the developing mammal as the
nucleoside adenosine. Adenosine levels increase rapidly with tissue hypoxia and …