Purpose Hexokinase-II (HK-II) is the key enzyme in the first rate-limiting step of glycolysis
that catalyzes the conversion of glucose to glucose-6-phosphate. Here, we examined the …

Radiotherapy is now widely used as a part of multidisciplinary treatment approaches for
advanced laryngeal carcinoma and preservation of laryngeal function. However, the …

Background: Hexokinase 2 (HK2) is a major glycolytic enzyme that plays a critical role in the
development of tumor metabolism. Triple negative breast cancers (TNBC) have high …

1364 Purpose: Hexokinase 2 (HK2) is a major glycolytic enzyme that plays a critical role in
the development of tumor metabolism. Triple negative breast cancers (TNBC) show highly …

In order to improve the sensitivity of cervical cancer cells to irradiation therapy, we targeted
hexokinase 2 (HK2), the first rate-limiting enzyme of glycolysis, and explore its role in …

First-line cancer therapies such as alkylating agents and radiation have limited survival
benefits for Glioblastoma (GBM) patients. Current research strongly supports the notion that …

The renin-angiotensin system (RAS) is a principal determinant of arterial blood pressure and
fluid and electrolyte balance. RAS component dysregulation was recently found in some …

Tumor cells preferentially use anaerobic glycolysis rather than oxidative phosphorylation to
generate energy. Hexokinase II (HK-II) is necessary for anaerobic glycolysis and displays …

Proliferating cancer cells preferentially use anaerobic glycolysis rather than oxidative
phosphorylation for energy production. Hexokinase 2 (HK2) is highly expressed in many …

Purpose/Objective: Activation of Ras signaling has been shown to increase the radiation
survival of tumor cells. Many tumors with wild type ras transmit signals through RAS …