Screening of 5′-methylthioadenosine nucleosidase enzyme inhibitors from traditional Chinese medicine and small molecular compounds by capillary …

K Yu, ME Yue, J Xu, TF Jiang - Chromatographia, 2020 - Springer
A capillary electrophoresis (CE) method was developed for the screening of 5′-
methylthioadenosine nucleosidase (MTAN) inhibitors in traditional Chinese drugs and small …

Screening of neuraminidase inhibitors from traditional Chinese medicines by integrating capillary electrophoresis with immobilized enzyme microreactor

H Zhao, Z Chen - Journal of Chromatography A, 2014 - Elsevier
A simple and effective neuraminidase-immobilized capillary microreactor was fabricated by
glutaraldehyde cross-linking technology for screening the neuraminidase inhibitors from …

Evaluation of Neuraminidase Inhibitory Activity of Compounds and Extracts from Traditional Medicines by HPLC‐FLD

G Yu, D Fang - International Journal of Analytical Chemistry, 2021 - Wiley Online Library
A simple and effective method was established and validated to determine 4‐
methylumbelliferone (4‐MU) for screening the natural neuraminidase inhibitors (NAIs) from …

Screening neuraminidase inhibitors from glycosaminoglycan and natural extract by capillary electrophoresis

TF Jiang, L Chong, ME Yue, YH Wang… - Journal of Analytical …, 2016 - Springer
An electrophoretically mediated microanalysis (EMMA) method for screening neuraminidase
inhibitors in depolymerized glycosaminoglycan and natural extracts is described. In the …

Screening acetylcholinesterase inhibitors from traditional Chinese medicines by paper-immobilized enzyme combined with capillary electrophoresis analysis

HH Zhao, YQ Liu, J Chen - Journal of Pharmaceutical and Biomedical …, 2020 - Elsevier
Discovering acetylcholinesterase (AChE) inhibitors is one of the important ways to develop
new drugs for the treatment of Alzheimer's disease. In this work, a simple strategy was …

Identification and Screening of Natural Neuraminidase Inhibitors from Reduning Injection via One‐Step High‐Performance Liquid Chromatography‐Fraction Collector …

L An, XA Yu, W Liu, J Li… - International Journal of …, 2020 - Wiley Online Library
Neuraminidase plays an essential role in the spread of influenza viruses via cleaving sialic
acids from the host cell receptors and virions. Neuraminidase has been regarded as an …

Impurities preparation of sodium tanshinone IIA sulfonate by high-speed counter-current chromatography and identification by liquid chromatography/multistage …

S Chen, X Zhao, Y Li, D Yang, T Zhou, G Fan - Journal of Chromatography …, 2013 - Elsevier
Sodium Tanshinone IIA Sulfonate, the chemical modification product of Tanshinon IIA
(STIIAS) is widely used in clinical treatment of angiocardiopathy, and the preparation of …

Screening of neuraminidase inhibitors from traditional Chinese medicine by transverse diffusion mediated capillary microanalysis

H Zhao, Z Chen - Biomicrofluidics, 2014 - pubs.aip.org
A transverse diffusion mediated capillary microanalysis method has been developed for
screening of neuraminidase inhibitors from traditional Chinese medicine. The enzyme …

Design and synthesis of potent “sulfur-free” transition state analogue inhibitors of 5′-methylthioadenosine nucleosidase and 5′-methylthioadenosine phosphorylase

AI Longshaw, F Adanitsch, JA Gutierrez… - Journal of medicinal …, 2010 - ACS Publications
5′-Methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN) is a dual
substrate bacterial enzyme involved in S-adenosylmethionine (SAM) related quorum …

Screening α-glucosidase inhibitors from traditional Chinese drugs by capillary electrophoresis with electrophoretically mediated microanalysis

LP Guo, TF Jiang, ZH Lv, YH Wang - Journal of pharmaceutical and …, 2010 - Elsevier
In the present study, we report the study by a combination of electrophoretically mediated
microanalysis method with a partial technique for screening α-glucosidase inhibitors from 21 …