Loss of vestibular hair cells is a common cause of balance disorders. Current treatment
options for bilateral vestibular dysfunction are limited. During development, atonal homolog …

In amniotes, head movements are encoded by two types of vestibular hair cells (type I and
type II) with unique morphology, physiology, and innervation. After hair cell destruction in …

Utricular hair cells (HCs) are mechanoreceptors required for vestibular function. After
damage, regeneration of mammalian utricular HCs is limited and regenerated HCs appear …

Loss of hair cells from vestibular epithelium results in balance dysfunction. The current
therapeutic regimen for vestibular diseases is limited. Upon injury or Atoh1 overexpression …

Herein, we will review molecular aspects of vestibular ear development and present them in
the context of evolutionary changes and hair cell regeneration. Several genes guide the …

The mammalian cochlea loses its ability to regenerate new hair cells prior to the onset of
hearing. In contrast, the adult vestibular system can produce new hair cells in response to …

The mammalian vestibular epithelium has a limited capacity for spontaneous hair cell
regeneration. The mechanism underlying the regeneration is not well understood. Because …

Hearing impairment due to the loss of sensory hair cells is permanent in humans.
Considerable interest targets the hair cell differentiation factor Atoh1 as a potential tool with …

Vestibular hair cells (HCs) are mechanoreceptors for the detection of head movement.
Vestibular HCs of adult mammals never completely regenerate after damage, resulting in …

Atoh1 overexpression is essential for hair cell (HC) regeneration in the sensory epithelium of
mammalian auditory and vestibular organs. However, Atoh1 overexpression alone cannot …