tRNAscan-SE 2.0: improved detection and functional classification of transfer RNA genes

PP Chan, BY Lin, AJ Mak, TM Lowe - Nucleic acids research, 2021 - academic.oup.com
Abstract tRNAscan-SE has been widely used for transfer RNA (tRNA) gene prediction for
over twenty years, developed just as the first genomes were decoded. With the massive …

GtRNAdb 2.0: an expanded database of transfer RNA genes identified in complete and draft genomes

PP Chan, TM Lowe - Nucleic acids research, 2016 - academic.oup.com
Transfer RNAs represent the largest, most ubiquitous class of non-protein coding RNA
genes found in all living organisms. The tRNAscan-SE search tool has become the de facto …

tRNAscan-SE On-line: integrating search and context for analysis of transfer RNA genes

TM Lowe, PP Chan - Nucleic acids research, 2016 - academic.oup.com
High-throughput genome sequencing continues to grow the need for rapid, accurate
genome annotation and tRNA genes constitute the largest family of essential, ever-present …

[图书][B] tRNAscan-SE: searching for tRNA genes in genomic sequences

PP Chan, TM Lowe - 2019 - Springer
Transfer RNAs are the largest, most complex non-coding RNA family, universal to all living
organisms. tRNAscan-SE has been the de facto tool for predicting tRNA genes in whole …

tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence

TM Lowe, SR Eddy - Nucleic acids research, 1997 - academic.oup.com
We describe a program, tRNAscan-SE, which identifies 99–100% of transfer RNA genes in
DNA sequence while giving less than one false positive per 15 gigabases. Two previously …

GtRNAdb: a database of transfer RNA genes detected in genomic sequence

PP Chan, TM Lowe - Nucleic acids research, 2009 - academic.oup.com
Transfer RNAs (tRNAs) represent the single largest, best-understood class of non-protein
coding RNA genes found in all living organisms. By far, the major source of new tRNAs is …

Noncanonical roles of tRNAs: tRNA fragments and beyond

Z Su, B Wilson, P Kumar, A Dutta - Annual review of genetics, 2020 - annualreviews.org
As one of the most abundant and conserved RNA species, transfer RNAs (tRNAs) are well
known for their role in reading the codons on messenger RNAs and translating them into …

A standardized ontology for naming tRNA-derived RNAs based on molecular origin

AD Holmes, PP Chan, Q Chen, P Ivanov, L Drouard… - Nature …, 2023 - nature.com
Transfer RNA (tRNA), well-studied as the key adaptor molecule in protein translation, is now
known to be processed into a large collection of smaller stable RNAs. High-throughput small …

ARWEN: a program to detect tRNA genes in metazoan mitochondrial nucleotide sequences

D Laslett, B Canbäck - Bioinformatics, 2008 - academic.oup.com
Motivation: Mitochondrial genomes encode their own transfer RNAs (tRNAs). These are
often degenerate in sequence and structure compared to tRNAs in their bacterial ancestors …

MINTmap: fast and exhaustive profiling of nuclear and mitochondrial tRNA fragments from short RNA-seq data

P Loher, AG Telonis, I Rigoutsos - Scientific reports, 2017 - nature.com
Transfer RNA fragments (tRFs) are an established class of constitutive regulatory molecules
that arise from precursor and mature tRNAs. RNA deep sequencing (RNA-seq) has greatly …