Understanding adaptogenic activity: specificity of the pharmacological action of adaptogens and other phytochemicals

A Panossian - Annals of the New York Academy of Sciences, 2017 - Wiley Online Library
Adaptogens are stress‐response modifiers that increase an organism's nonspecific
resistance to stress by increasing its ability to adapt and survive. The classical reductionist …

[HTML][HTML] Effects of adaptogens on the central nervous system and the molecular mechanisms associated with their stress—protective activity

A Panossian, G Wikman - Pharmaceuticals, 2010 - mdpi.com
Adaptogens were initially defined as substances that enhance the “state of non-specific
resistance” in stress, a physiological condition that is linked with various disorders of the …

Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress‐and aging‐related diseases

AG Panossian, T Efferth, AN Shikov… - Medicinal research …, 2021 - Wiley Online Library
Adaptogens comprise a category of herbal medicinal and nutritional products promoting
adaptability, resilience, and survival of living organisms in stress. The aim of this review was …

Network pharmacology of adaptogens in the assessment of their pleiotropic therapeutic activity

A Panossian, T Efferth - Pharmaceuticals, 2022 - mdpi.com
The reductionist concept, based on the ligand–receptor interaction, is not a suitable model
for adaptogens, and herbal preparations affect multiple physiological functions, revealing …

[PDF][PDF] Adaptogens in mental and behavioral disorders

AG Panossian - Psychiatric Clinics, 2013 - researchgate.net
The term adaptogen was introduced into scientific literature in 1958 to denote substances
that increase the “state of nonspecific resistance” during stress, based on Hans Selye's …

Plant adaptogens III. Earlier and more recent aspects and concepts on their mode of action

A Panossian, G Wikman, H Wagner - Phytomedicine, 1999 - Elsevier
The term adaptogen was originally coined in 1947 by NV Lazarev, a pharmacologist, to
describe the unexpected effects of dibazol (2-benzylbenzimidazol), an arterial dilator …

Plant adaptogens

H Wagner, H Nörr, H Winterhoff - Phytomedicine, 1994 - Elsevier
The term adaptogen has not yet been accepted in medicine. This is probably due to the
difficulties in discriminating adaptogenic drugs from immunostimulators, anabolic drugs …

Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity

A Panossian, G Wikman - Current clinical pharmacology, 2009 - ingentaconnect.com
The aim of this review article is to assess the level of scientific evidence presented by clinical
trials of adaptogens in fatigue, and to provide a rationale at the molecular level for verified …

A current status of adaptogens: natural remedy to stress

VS Pawar, H Shivakumar - Asian Pacific Journal of Tropical Disease, 2012 - Elsevier
Stress is a normal part of everyday life but it is important to be able to use tools for its
management otherwise chronic stress, if left untreated, can lead to a variety of stress related …

[图书][B] Adaptogens: herbs for strength, stamina, and stress relief

D Winston - 2019 - books.google.com
An updated and expanded edition of the definitive guide to adaptogenic herbs• Includes a
Materia Medica with monographs covering 25 adaptogens, including eleuthero, ginseng …