[PDF][PDF] Novel coumarin derivatives as potential HDAC2 inhibitors : in silico study.
P Dhakla, R Dutt, D Rani - 2022 - agribiop.com
Designing of selective HDAC2 inhibitors will have less adverse effects and better safety
profiles. For HDAC2 selectivity, the coumarin derivatives were designed according to the …
profiles. For HDAC2 selectivity, the coumarin derivatives were designed according to the …
Identification of hydroxamic acid based selective HDAC1 inhibitors: Computer aided drug design studies
P Patel, VK Patel, A Singh, T Jawaid… - … -Aided Drug Design, 2019 - ingentaconnect.com
Background: Overexpression of Histone deacetylase 1 (HDAC1) is responsible for
carcinogenesis by promoting epigenetic silence of tumour suppressor genes. Thus, HDAC1 …
carcinogenesis by promoting epigenetic silence of tumour suppressor genes. Thus, HDAC1 …
3D-QSAR and molecular docking studies of n-(2-aminophenyl)-benzamide derivatives as inhibitors of HDAC2
N Kaur, K Singh - Research Journal of Pharmacy and …, 2014 - indianjournals.com
Inhibitors of HDACs are an important emerging class of drugs for the treatment of cancers. 3-
Dimensional quantitative structure-activity relationship (3D-QSAR) studies were performed …
Dimensional quantitative structure-activity relationship (3D-QSAR) studies were performed …
Design, synthesis, biological evaluation and molecular docking study of arylcarboxamido piperidine and piperazine-based hydroxamates as potential HDAC8 …
P Trivedi, N Adhikari, SA Amin, Y Bobde… - European Journal of …, 2019 - Elsevier
HDAC8 has been established as one of the vital targets as far as the cancer is concerned.
Different compounds having potential HDAC inhibitory activity have been approved by …
Different compounds having potential HDAC inhibitory activity have been approved by …
Development of New Inhibitors of HDAC1–3 Enzymes Aided by In Silico Design Strategies
N Cheshmazar, S Hemmati… - Journal of Chemical …, 2022 - ACS Publications
Histone deacetylases (HDACs) are overexpressed in cancer, and their inhibition shows
promising results in cancer therapy. In particular, selective class I HDAC inhibitors such as …
promising results in cancer therapy. In particular, selective class I HDAC inhibitors such as …
Discovery of Novel Small Molecule HDAC1, 2, 3 Inhibitors--Combined Receptor-Based and Ligand-Based Virtual Screening Strategy
Y Wu, B Zhang, X Dong, S Ma… - Letters in Drug Design & …, 2022 - ingentaconnect.com
Aims: This study aims to investigate and validate the potential drug target to HDAC1.
Background: Human histone deacetylase 1 (HDAC1) can catalyze the deacetylation of …
Background: Human histone deacetylase 1 (HDAC1) can catalyze the deacetylation of …
Discovery of novel hit compounds as potential HDAC1 inhibitors: The case of ligand-and structure-based virtual screening
Histone deacetylases (HDACs) as an important family of epigenetic regulatory enzymes are
implicated in the onset and progression of carcinomas. As a result, HDAC inhibition has …
implicated in the onset and progression of carcinomas. As a result, HDAC inhibition has …
Design, synthesis and biological evaluation of new HDAC1 and HDAC2 inhibitors endowed with ligustrazine as a novel cap moiety
Introduction Histone deacetylases (HDACs) represent one of the most validated cancer
targets. The inhibition of HDACs has been proven to be a successful strategy for the …
targets. The inhibition of HDACs has been proven to be a successful strategy for the …
Hydroxamic acid derivatives as selective HDAC3 inhibitors: computer-aided drug design strategies
P Patel, SK Shrivastava, P Sharma… - Journal of …, 2024 - Taylor & Francis
Histone deacetylases (HDACs) are critical epigenetic drug targets that have gained
significant attention in the scientific community for the treatment of cancer. The currently …
significant attention in the scientific community for the treatment of cancer. The currently …
Design of Potent HDAC Inhibitors: Pharmacophore, Fingerprint Based 2D-QSAR, Atom-Based 3D-QSAR, and Molecular Docking Studies
F Fathima, G Shenoy - Proceedings of International Conference on …, 2020 - papers.ssrn.com
Histone deacetylase (HDAC) is considered as a potential target for the treatment of cancers,
cardiovascular and neurodegenerative disorders. Among the reported 18 HDACs, HDAC …
cardiovascular and neurodegenerative disorders. Among the reported 18 HDACs, HDAC …