Background Sensorineural hearing loss is the most common sensory deficit in the world,
with nearly 300 million affected individuals. The problem is multifactorial and can arise from …

Neurosensory responses of hearing and balance are mediated by receptors in specialized
neuroepithelial sensory cells. Any disruption of the biochemical and molecular pathways …

Hearing loss is a global health problem with profound socioeconomic impact. We contend
that acquired hearing loss is mainly a modern disorder caused by man-made noise and …

Sound detection by inner ear hair cells requires tip links that interconnect mechanosensory
stereocilia and convey force to yet unidentified transduction channels. Current models …

Millions of people worldwide suffer from hearing and balance disorders caused by loss of
the sensory hair cells that convert sound vibrations and head movements into electrical …

Mechanosensation is a primitive and somewhat ubiquitous sense. At the inner ear, sensory
hair cells are refined to enhance sensitivity, dynamic range and frequency selectivity. Thirty …

Mechanosensory hair cells of the mature mammalian organ of Corti do not regenerate;
consequently, loss of hair cells leads to permanent hearing loss. Although nonmammalian …

The inner ear of mammals uses neurosensory cells derived from the embryonic ear for
mechanoelectric transduction of vestibular and auditory stimuli (the hair cells) and conducts …

Hearing loss due to damage to auditory hair cells is normally irreversible because
mammalian hair cells do not regenerate. Here, we show that new hair cells can be induced …

Sensory hair cells of the inner ear are responsible for translating auditory or vestibular
stimuli into electrical energy that can be perceived by the nervous system. Although hair …