Transgenic mice expressing proteins altering polyamine levels in a tissue-specific manner
have considerable promise for evaluation of the roles of polyamines in normal, hypertrophic …

Ornithine decarboxylase, a critical regulatory enzyme for polyamine biosynthesis, is highly
inducible by growth-promoting stimuli in mouse epidermis but the enzyme level is only …

Elevated polyamine levels are characteristic of many types of neoplastic cells and tissues.
We demonstrate that in transgenic mice overexpressing ornithine decarboxylase in skin …

The bovine keratin 6 gene promoter was used to target expression of spermidine/spermine
N 1-acetyltransferase (SSAT) to epidermal keratinocytes in the hair follicle of transgenic …

Cloning of genes related to polyamine metabolism has enabled the generation of
genetically modified mice and rats overproducing or devoid of proteins encoded by these …

Studies over many years have suggested that increased polyamine synthesis may be
necessary for neoplastic growth. This review summarizes recent work on the regulation of …

Polyamines are small polycationic molecules that have been implicated in cell growth,
differentiation and transformation. A possible mechanism for their involvement in these …

Previous studies have shown that keratin 6 (K6)–spermidine/spermine N 1-acetyltransferase
(SSAT) transgenic mice, which modestly over-express SSAT in the skin, are more sensitive …

Elevated levels of polyamines have long been associated with skin tumorigenesis. Tightly
regulated metabolism of polyamines is critical for cell survival and normal skin homeostasis …

The polyamines putrescine, spermidine and spermine are natural components of all living
cells. Although their exact cellular functions are still largely unknown, a constant supply of …