The tumor microenvironment (TME) significantly influences cancer evolution and therapeutic
efficacy. Targeting biofunctional molecules to the TME has long been appreciated as a …

Proteases have a fundamental role in maintaining physiological homeostasis, but their
dysregulation results in severe activity imbalance and pathological conditions, including …

The cathepsin B-responsive prodrugs are promising strategies to reduce the serious
adverse effects of anticancer drugs by improving the cancer selectivity that can be …

Enzymatic dysregulation in tumor and intracellular microenvironments has made this
property a tremendously promising responsive element for efficient diagnostics, carrier …

Cathepsin B is a lysosomal cysteine protease, contributing to vital cellular homeostatic
processes including protein turnover, macroautophagy of damaged organelles, antigen …

The past few decades have seen great progress in the exploration of nanoparticles (NPs) as
novel tools for cancer treatments and diagnosis. Practical and reliable application of …

Nanozymes have entranced considerable concern since they provide a likelihood strategy
for performing the integration of diagnosis and therapy. Nanozymes, as emerging …

Bioenzymes that catalyze reactions within living systems show a great promise for cancer
therapy, particularly when they are integrated with nanoparticles to improve their …

Nanozymes, as a type of nanomaterials with enzymatic catalytic activity, have demonstrated
tremendous potential in cancer treatment owing to their unique biomedical properties …

An ideal cancer nanomedicine should precisely deliver therapeutics to its intracellular target
within tumor cells. However, the multiple biological barriers seriously hinder their delivery …