[HTML][HTML] Asymmetric centromeres differentially coordinate with mitotic machinery to ensure biased sister chromatid segregation in germline stem cells

R Ranjan, J Snedeker, X Chen - Cell stem cell, 2019 - cell.com
Many stem cells utilize asymmetric cell division (ACD) to produce a self-renewed stem cell
and a differentiating daughter cell. How non-genic information could be inherited …

[HTML][HTML] Asymmetric distribution of histones during Drosophila male germline stem cell asymmetric divisions

V Tran, L Feng, X Chen - Chromosome research, 2013 - Springer
It has long been known that epigenetic changes are inheritable. However, except for DNA
methylation, little is known about the molecular mechanisms of epigenetic inheritance. Many …

Asymmetric histone inheritance in asymmetrically dividing stem cells

M Wooten, R Ranjan, X Chen - Trends in Genetics, 2020 - cell.com
Epigenetic mechanisms play essential roles in determining distinct cell fates during the
development of multicellular organisms. Histone proteins represent crucial epigenetic …

[HTML][HTML] Differential condensation of sister chromatids acts with Cdc6 to ensure asynchronous S-phase entry in Drosophila male germline stem cell lineage

R Ranjan, J Snedeker, M Wooten, C Chu, S Bracero… - Developmental cell, 2022 - cell.com
During Drosophila melanogaster male germline stem cell (GSC) asymmetric division,
preexisting old versus newly synthesized histones H3 and H4 are asymmetrically inherited …

Fly meets yeast: checking the correct orientation of cell division

G Pereira, YM Yamashita - Trends in Cell Biology, 2011 - cell.com
Cell division is generally thought to be a process that produces an exact copy of the mother
cell by precisely replicating its genomic DNA, doubling organelles, and segregating them …

Centrosome misorientation mediates slowing of the cell cycle under limited nutrient conditions in Drosophila male germline stem cells

TM Roth, CYA Chiang, M Inaba, H Yuan… - Molecular Biology of …, 2012 - Am Soc Cell Biol
Drosophila male germline stem cells (GSCs) divide asymmetrically, balancing self-renewal
and differentiation. Although asymmetric stem cell division balances between self-renewal …

Asymmetric Histone Inheritance: Establishment, Recognition, and Execution

JA Urban, R Ranjan, X Chen - Annual review of genetics, 2022 - annualreviews.org
The discovery of biased histone inheritance in asymmetrically dividing Drosophila
melanogaster male germline stem cells demonstrates one means to produce two distinct …

Asymmetric assembly of centromeres epigenetically regulates stem cell fate

AA Dattoli, BL Carty, AM Kochendoerfer… - Journal of Cell …, 2020 - rupress.org
Centromeres are epigenetically defined by CENP-A–containing chromatin and are essential
for cell division. Previous studies suggest asymmetric inheritance of centromeric proteins …

Regulation of Drosophila germline stem cells

EW Kahney, JC Snedeker, X Chen - Current opinion in cell biology, 2019 - Elsevier
The asymmetric division of adult stem cells into one self-renewing stem cell and one
differentiating cell is critical for maintaining homeostasis in many tissues. One paradigmatic …

[HTML][HTML] Breaking symmetry− asymmetric histone inheritance in stem cells

J Xie, M Wooten, V Tran, X Chen - Trends in cell biology, 2017 - cell.com
Asymmetric cell division (ACD) gives rise to two daughter cells with distinct fates. ACD is
widely used during development and by many types of adult stem cells during tissue …