Supersaturating formulations are widely used to improve the oral bioavailability of poorly
soluble drugs. However, supersaturated solutions are thermodynamically unstable and such …

Objectives Supersaturating formulations hold great promise for delivery of poorly soluble
active pharmaceutical ingredients (APIs). To profit from supersaturating formulations …

Supersaturation is a promising strategy to improve gastrointestinal absorption of poorly
water-soluble drugs. Supersaturation is a metastable state and therefore dissolved drugs …

Use of supersaturable formulations has been demonstrated as an effective approach to
improve solubility and oral absorption of poorly water-soluble compounds. In supersaturable …

Supersaturating drug delivery systems can enhance the oral bioavailability of poorly soluble
drug compounds. Supersaturation of such compounds has been studied in many different …

The presence of polymers within solid dose forms, such as solid dispersions, or liquid or
semisolid formulations, such as lipid-based formulations, can promote the maintenance of …

There is increasing interest in formulating combination products that contain two or more
drugs. Furthermore, it is also common for different drug products to be taken simultaneously …

With the increasing number of poorly water-soluble compounds in contemporary drug
discovery pipelines, the concept of supersaturation as an effective formulation approach for …

Phosphate buffer is predominantly used instead of the more physiological bicarbonate
buffer, as the latter requires a technical solution of adequate gas mixing. Recent pioneering …

This review focuses on options available to a pharmaceutical scientist to predict in vivo
supersaturation and precipitation of poorly water-soluble drugs. As no single device or …