Type I interferons and SARS-CoV-2: from cells to organisms
Type I interferons (IFNs) have broad and potent antiviral activity. We review the interplay
between type I IFNs and SARS-CoV-2. Human cells infected with SARS-CoV-2 in vitro …
between type I IFNs and SARS-CoV-2. Human cells infected with SARS-CoV-2 in vitro …
Type I interferons in COVID-19 pathogenesis
Simple Summary The innate antiviral immune response is essential to limit virus replication
at early stages of infection, thus preventing viral spread and pathogenesis. Nevertheless …
at early stages of infection, thus preventing viral spread and pathogenesis. Nevertheless …
[HTML][HTML] Type I and type III interferons–induction, signaling, evasion, and application to combat COVID-19
A Park, A Iwasaki - Cell host & microbe, 2020 - cell.com
Coronavirus disease 2019 (COVID-19) is a global pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). Without approved antiviral therapeutics …
respiratory syndrome coronavirus 2 (SARS-CoV-2). Without approved antiviral therapeutics …
Protective potentials of type III interferons in COVID-19 patients: lessons from differential properties of type I-and III interferons
A Jafarzadeh, M Nemati, B Saha, YD Bansode… - Viral …, 2021 - liebertpub.com
While an appropriately regulated production of interferons (IFNs) performs a fundamental
role in the defense against coronaviruses such as severe acute respiratory syndrome …
role in the defense against coronaviruses such as severe acute respiratory syndrome …
Experimental and natural evidence of SARS-CoV-2-infection-induced activation of type I interferon responses
Type I interferons (IFNs) are our first line of defense against virus infection. Recent studies
have suggested the ability of SARS-CoV-2 proteins to inhibit IFN responses. Emerging data …
have suggested the ability of SARS-CoV-2 proteins to inhibit IFN responses. Emerging data …
The role of type I interferons in the pathogenesis and treatment of COVID-19
G Schreiber - Frontiers in immunology, 2020 - frontiersin.org
Type I interferons (IFN-I) were first discovered over 60 years ago in a classical experiment by
Isaacs and Lindenman, who showed that IFN-Is possess antiviral activity. Later, it became …
Isaacs and Lindenman, who showed that IFN-Is possess antiviral activity. Later, it became …
Interferon induction, evasion, and paradoxical roles during SARS‐CoV‐2 infection
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the causative agent of
coronavirus disease 2019 (COVID‐19), has caused millions of deaths in the past two years …
coronavirus disease 2019 (COVID‐19), has caused millions of deaths in the past two years …
Interfering with interferons: A critical mechanism for critical COVID-19 pneumonia
HC Su, H Jing, Y Zhang… - Annual Review of …, 2023 - annualreviews.org
Infection with SARS-CoV-2 results in clinical outcomes ranging from silent or benign
infection in most individuals to critical pneumonia and death in a few. Genetic studies in …
infection in most individuals to critical pneumonia and death in a few. Genetic studies in …
[HTML][HTML] Dual nature of type I interferons in SARS-CoV-2-induced inflammation
Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). The ability of our cells to secrete type I …
respiratory syndrome coronavirus 2 (SARS-CoV-2). The ability of our cells to secrete type I …
Differential interferon-α subtype induced immune signatures are associated with suppression of SARS-CoV-2 infection
J Schuhenn, TL Meister, D Todt… - Proceedings of the …, 2022 - National Acad Sciences
Type I interferons (IFN-I) exert pleiotropic biological effects during viral infections, balancing
virus control versus immune-mediated pathologies, and have been successfully employed …
virus control versus immune-mediated pathologies, and have been successfully employed …