Prodrugs of triterpenoids and their derivatives

M Zhou, RH Zhang, M Wang, GB Xu, SG Liao - European Journal of …, 2017 - Elsevier
Triterpenoids are structurally diverse organic compounds that exist widely as natural
products. Triterpenoids and their derivatives possess a wide range of biological effects …

Nanoformulations for delivery of pentacyclic triterpenoids in anticancer therapies

A Kaps, P Gwiazdoń, E Chodurek - Molecules, 2021 - mdpi.com
The search for safe and effective anticancer therapies is one of the major challenges of the
21st century. The ineffective treatment of cancers, classified as civilization diseases …

Structure and activity of pentacyclic triterpenes codrugs. A review

J Żwawiak, A Pawełczyk, D Olender… - Mini Reviews in …, 2021 - ingentaconnect.com
Triterpenes are a wide and important group of compounds that have several promising
pharmacological properties, such as hepatoprotective, anti-inflammatory, anti-HIV …

Plant-derived triterpenoids and analogues as antitumor and anti-HIV agents

RY Kuo, K Qian, SL Morris-Natschke, KH Lee - Natural product reports, 2009 - pubs.rsc.org
Covering: January 2006 to December 2008 This article reviews the antitumor and anti-HIV
activities of naturally occurring triterpenoids, including the lupane, ursane, oleanane …

Pentacyclic triterpenes of the lupane, oleanane and ursane group as tools in cancer therapy

MN Laszczyk - Planta medica, 2009 - thieme-connect.com
Today cancer treatment is not only a question of eliminating cancer cells by induction of cell
death. New therapeutic strategies also include targeting the tumour microenvironment …

Plant-derived triterpenoids as potential antineoplastic agents

WN Setzer, MC Setzer - Mini reviews in medicinal chemistry, 2003 - ingentaconnect.com
Man has relied on plants as a source of medicinal agents for centuries. Today, with the
specter of antibiotic resistance, emerging infectious diseases, and cancers, phytochemicals …

Saponins of selected triterpenoids as potential therapeutic agents: A review

U Bildziukevich, M Wimmerová, Z Wimmer - Pharmaceuticals, 2023 - mdpi.com
Saponins represent important natural derivatives of plant triterpenoids that are secondary
plant metabolites. Saponins, also named glycoconjugates, are available both as natural and …

Semisynthetic derivatives of pentacyclic triterpenes bearing heterocyclic moieties with therapeutic potential

G Nistor, C Trandafirescu, A Prodea, A Milan, A Cristea… - Molecules, 2022 - mdpi.com
Medicinal plants have been used by humans since ancient times for the treatment of various
diseases and currently represent the main source of a variety of phytocompounds, such as …

Natural product triterpenoids and their semi-synthetic derivatives with potential anticancer activity

Y Ren, AD Kinghorn - Planta Medica, 2019 - thieme-connect.com
Triterpenoids are distributed widely in higher plants and are of interest because of their
structural diversity and broad range of bioactivities. In particular, there is a very large …

Modulation of tumour-related signaling pathways by natural pentacyclic triterpenoids and their semisynthetic derivatives

AV Markov, MA Zenkova… - Current Medicinal …, 2017 - ingentaconnect.com
Pentacyclic triterpenoids are a large class of natural isoprenoids that are widely
biosynthesized in higher plants. These compounds are potent anticancer agents that exhibit …