Non-coding RNA networks in cancer

E Anastasiadou, LS Jacob, FJ Slack - Nature Reviews Cancer, 2018 - nature.com
Thousands of unique non-coding RNA (ncRNA) sequences exist within cells. Work from the
past decade has altered our perception of ncRNAs from'junk'transcriptional products to …

Non-coding RNAs, epigenetics, and cancer: tying it all together

HJ Ferreira, M Esteller - Cancer and Metastasis Reviews, 2018 - Springer
While only a small part of the human genome encodes for proteins, biological functions for
the so-called junk genome are increasingly being recognized through high-throughput …

Large non-coding RNAs: missing links in cancer?

M Huarte, JL Rinn - Human molecular genetics, 2010 - academic.oup.com
Cellular homeostasis is achieved by the proper balance of regulatory networks that if
disrupted can lead to cellular transformation. These cell circuits are fine-tuned and …

[HTML][HTML] Noncoding RNA in oncogenesis: a new era of identifying key players

G Deng, G Sui - International journal of molecular sciences, 2013 - mdpi.com
New discoveries and accelerating progresses in the field of noncoding RNAs (ncRNAs)
continuously challenges our deep-rooted doctrines in biology and sometimes our …

[HTML][HTML] Noncoding RNA: RNA regulatory networks in cancer

JJ Chan, Y Tay - International journal of molecular sciences, 2018 - mdpi.com
Noncoding RNAs (ncRNAs) constitute the majority of the human transcribed genome. This
largest class of RNA transcripts plays diverse roles in a multitude of cellular processes, and …

[HTML][HTML] The role of non-coding RNAs in oncology

FJ Slack, AM Chinnaiyan - Cell, 2019 - cell.com
For decades, research into cancer biology focused on the involvement of protein-coding
genes. Only recently was it discovered that an entire class of molecules, termed non-coding …

[HTML][HTML] Non-coding RNAs in cancer initiation and progression and as novel biomarkers

SP Nana-Sinkam, CM Croce - Molecular oncology, 2011 - Elsevier
Cancer represents a complex group of heterogeneous diseases. While many cancers share
fundamental biological processes (hallmarks of cancer) necessary for their development …

[HTML][HTML] Non-coding RNAs: the riddle of the transcriptome and their perspectives in cancer

MA Diamantopoulos, P Tsiakanikas… - Annals of translational …, 2018 - ncbi.nlm.nih.gov
Non-coding RNAs (ncRNAs) constitute a heterogeneous group of RNA molecules in terms
of biogenesis, biological function as well as length and structure. These biological …

Non-coding RNAs: the new central dogma of cancer biology

PE Saw, X Xu, J Chen, EW Song - Science China Life Sciences, 2021 - Springer
The central dogma of molecular biology states that the functions of RNA revolve around
protein translation. Until the last decade, most researches were geared towards …

Long noncoding RNAs: at the intersection of cancer and chromatin biology

AM Schmitt, HY Chang - Cold Spring …, 2017 - perspectivesinmedicine.cshlp.org
Although only 2% of the genome encodes protein, RNA is transcribed from the majority of
the genetic sequence, suggesting a massive degree of cellular functionality is programmed …