Optimal methods of inner ear drug delivery will depend on toxicity, therapeutic dose range,
and characteristics of the agent to be delivered. Advanced therapy development will likely …

Inner ear drug delivery methods include systemic, intratympanic, and intracochlear
administration. Therapeutic technologies aim to overcome delivery barriers and to improve …

Numerous disease processes cause inner ear dysfunction and represent an opportunity for
therapeutic intervention. Hearing loss is the common endpoint of many inner ear disorders …

Many inner ear disorders cannot be adequately treated by systemic drug delivery. A blood-
cochlear barrier exists, similar physiologically to the blood-brain barrier, which limits the …

Hearing aids or cochlear implants constitute almost exclusively the treatment options
currently available to patients suffering from sensorineural hearing loss and related …

The main challenge for drug treatments of the inner ear is to produce a therapeutic drug
concentration at desired locations in the ear without disrupting other organ systems …

Inner ear diseases are not adequately treated by systemic drug administration mainly
because of the blood–perilymph barrier that reduces exchanges between plasma and inner …

Introduction: Diseases of the inner ear include those of the auditory and vestibular systems,
and frequently result in disabling hearing loss or vertigo. Despite a rapidly expanding …

Introduction: Advances in molecular biology and in the basic understanding of the
mechanisms associated with sensorineural hearing loss and other diseases of the inner ear …

Objectives The method of drug delivery directly into the cochlea with an implantable pump
connected to a CI electrode array ensures long-term delivery and effective dose control, and …