Topographical patterning has recently attracted lots of attention in regulating cell fate,
understanding the mechanism of cell–microenvironment interactions, and solving the great …

Stem cells have been one of the ideal sources for tissue regeneration owing to their
capability of self-renewal and differentiation. In vivo, the extracellular microenvironment …

Development of functional tissues often requires spatially controlled growth of cells over 2D
surfaces or 3D substrates to maintain their distinct cellular functions; particularly it is …

Surface patterning becomes an important tool in biomedical research and applications, as it
enables systematic investigation of cell-biomaterial interaction as well as rapid, high …

Cellular behavior can be influenced by the chemical and physical surface characteristics of
biomedical substrates. To understand the relationships between various topographical …

Cells interact with various nanoscaled topographical and biochemical cues in their cellular
macromolecular environment. Nanotopography recreates or mimic the cellular …

In this chapter, we will particularly focus on topography, both at micro-and nanoscale, and its
effect on cellular functions. An overview on the way cells recognize these specific clues …

Influencing cell behavior from proliferation to differentiation using substrate or implant
topography is an attractive strategy for regenerative medicine applications. Substrate …

Chemical and topographic substrate surface patterning is recognized as a powerful tool for
regulating cell functions. We discuss the relative role of scale and pattern of chemically and …

Living cells receive biochemical and physical information from the surrounding
microenvironment and respond to this information. Multiscale hierarchical substrates with …