A genome-wide association study discovers 46 loci of the human metabolome in the Hispanic Community Health Study/Study of Latinos
Variation in levels of the human metabolome reflect changes in homeostasis, providing a
window into health and disease. The genetic impact on circulating metabolites in Hispanics …
window into health and disease. The genetic impact on circulating metabolites in Hispanics …
Genetic determinants influencing human serum metabolome among African Americans
B Yu, Y Zheng, D Alexander, AC Morrison… - PLoS …, 2014 - journals.plos.org
Phenotypes proximal to gene action generally reflect larger genetic effect sizes than those
that are distant. The human metabolome, a result of multiple cellular and biological …
that are distant. The human metabolome, a result of multiple cellular and biological …
Whole-genome sequencing analysis of human metabolome in multi-ethnic populations
EV Feofanova, MR Brown, T Alkis, AM Manuel… - nature …, 2023 - nature.com
Circulating metabolite levels may reflect the state of the human organism in health and
disease, however, the genetic architecture of metabolites is not fully understood. We have …
disease, however, the genetic architecture of metabolites is not fully understood. We have …
Metabolome genome-wide association study identifies 74 novel genomic regions influencing plasma metabolites levels
Metabolites are small products of metabolism that provide a snapshot of the wellbeing of an
organism and the mechanisms that control key physiological processes involved in health …
organism and the mechanisms that control key physiological processes involved in health …
Whole-genome sequencing identifies common-to-rare variants associated with human blood metabolites
T Long, M Hicks, HC Yu, WH Biggs, EF Kirkness… - Nature …, 2017 - nature.com
Genetic factors modifying the blood metabolome have been investigated through genome-
wide association studies (GWAS) of common genetic variants and through exome …
wide association studies (GWAS) of common genetic variants and through exome …
Human metabolic individuality in biomedical and pharmaceutical research
Genome-wide association studies (GWAS) have identified many risk loci for complex
diseases, but effect sizes are typically small and information on the underlying biological …
diseases, but effect sizes are typically small and information on the underlying biological …
A genome-wide association study of the human metabolome in a community-based cohort
Because metabolites are hypothesized to play key roles as markers and effectors of
cardiometabolic diseases, recent studies have sought to annotate the genetic determinants …
cardiometabolic diseases, recent studies have sought to annotate the genetic determinants …
Genome analysis and pleiotropy assessment using causal networks with loss of function mutation and metabolomics
Background Many genome-wide association studies have detected genomic regions
associated with traits, yet understanding the functional causes of association often remains …
associated with traits, yet understanding the functional causes of association often remains …
Heritability estimates for 361 blood metabolites across 40 genome-wide association studies
Metabolomics examines the small molecules involved in cellular metabolism. Approximately
50% of total phenotypic differences in metabolite levels is due to genetic variance, but …
50% of total phenotypic differences in metabolite levels is due to genetic variance, but …
Genetic determinants of metabolism in health and disease: from biochemical genetics to genome-wide associations
Increasingly sophisticated measurement technologies have allowed the fields of
metabolomics and genomics to identify, in parallel, risk factors of disease; predict drug …
metabolomics and genomics to identify, in parallel, risk factors of disease; predict drug …