Variation in levels of the human metabolome reflect changes in homeostasis, providing a
window into health and disease. The genetic impact on circulating metabolites in Hispanics …

Phenotypes proximal to gene action generally reflect larger genetic effect sizes than those
that are distant. The human metabolome, a result of multiple cellular and biological …

Circulating metabolite levels may reflect the state of the human organism in health and
disease, however, the genetic architecture of metabolites is not fully understood. We have …

Metabolites are small products of metabolism that provide a snapshot of the wellbeing of an
organism and the mechanisms that control key physiological processes involved in health …

Genetic factors modifying the blood metabolome have been investigated through genome-
wide association studies (GWAS) of common genetic variants and through exome …

Genome-wide association studies (GWAS) have identified many risk loci for complex
diseases, but effect sizes are typically small and information on the underlying biological …

Because metabolites are hypothesized to play key roles as markers and effectors of
cardiometabolic diseases, recent studies have sought to annotate the genetic determinants …

Background Many genome-wide association studies have detected genomic regions
associated with traits, yet understanding the functional causes of association often remains …

Metabolomics examines the small molecules involved in cellular metabolism. Approximately
50% of total phenotypic differences in metabolite levels is due to genetic variance, but …

Increasingly sophisticated measurement technologies have allowed the fields of
metabolomics and genomics to identify, in parallel, risk factors of disease; predict drug …