Excessive and misplaced iron promotes an array of neurodegenerative and endocrine
diseases as well as cardiomyopathy, arthropathy, neoplasia and infection. Vertebrates …

The brain shares with other organs the need for a constant and readily available supply of
iron and has a similar array of proteins available to it for iron transport, storage, and …

Excess free iron generates oxidative stress that hallmarks diseases of aging. The
observation that patients with Alzheimer's disease or Parkinson's disease show a dramatic …

All cells in organisms ranging from yeast to humans utilize iron as a cofactor or structural
element of proteins that function in diverse and critical cellular functions. However …

There is increasing evidence that iron is involved in the mechanisms that underlie many
neurodegenerative diseases. Conditions such as neuroferritinopathy and Friedreich ataxia …

Iron is a crucial transition metal for life and is the most abundant transition metal in the brain.
However, iron's biological utility as an effective redox cycling metal also endows it with the …

This chapter discusses one of the hypotheses regarding the pathogenesis of Alzheimer's
Disease (AD) which is the role of toxic metals. In the AD brain, ferritin-positive microglia and …

Iron has emerged as a significant cause of neurotoxicity in several neurodegenerative
conditions, including Alzheimer's disease (AD), Parkinson's disease (PD), sporadic …

Brains from patients with Alzheimer disease (AD) show a disruption in the metabolism of
iron, such that there is an accumulation of iron in senile plaques, and an altered distribution …

Increasing evidence implicates a role of iron in the pathogenesis of numerous
neurodegenerative diseases due to its capacity to enhance production of toxic reactive …