Single cell analysis of cribriform prostate cancer reveals cell intrinsic and tumor microenvironmental pathways of aggressive disease
Cribriform prostate cancer, found in both invasive cribriform carcinoma (ICC) and intraductal
carcinoma (IDC), is an aggressive histological subtype that is associated with progression to …
carcinoma (IDC), is an aggressive histological subtype that is associated with progression to …
A prostate cancer “nimbosus”: genomic instability and SChLAP1 dysregulation underpin aggression of intraductal and cribriform subpathologies
Background Intraductal carcinoma (IDC) and cribriform architecture (CA) represent
unfavorable subpathologies in localized prostate cancer. We recently showed that IDC …
unfavorable subpathologies in localized prostate cancer. We recently showed that IDC …
Genetic and epigenetic determinants of aggressiveness in cribriform carcinoma of the prostate
H Elfandy, J Armenia, F Pederzoli, E Pullman… - Molecular Cancer …, 2019 - AACR
Among prostate cancers containing Gleason pattern 4, cribriform morphology is associated
with unfavorable clinicopathologic factors, but its genetic features and association with long …
with unfavorable clinicopathologic factors, but its genetic features and association with long …
Cribriform prostate cancer: clinical pathologic and molecular considerations
AB Hesterberg, JB Gordetsky, PJ Hurley - Urology, 2021 - Elsevier
Intraductal cribriform (IDC) and invasive cribriform morphologies are associated with worse
prostate cancer outcomes. Limited retrospective studies have associated IDC and cribriform …
prostate cancer outcomes. Limited retrospective studies have associated IDC and cribriform …
Bimodal CD40/Fas-dependent crosstalk between iNKT cells and tumor-associated macrophages impairs prostate cancer progression
F Cortesi, G Delfanti, A Grilli, A Calcinotto, F Gorini… - Cell reports, 2018 - cell.com
Heterotypic cellular and molecular interactions in the tumor microenvironment (TME) control
cancer progression. Here, we show that CD1d-restricted invariant natural killer (iNKT) cells …
cancer progression. Here, we show that CD1d-restricted invariant natural killer (iNKT) cells …
Cribriform and intraductal prostate cancer are associated with increased genomic instability and distinct genomic alterations
Background Invasive cribriform and intraductal carcinoma (CR/IDC) is associated with
adverse outcome of prostate cancer patients. The aim of this study was to determine the …
adverse outcome of prostate cancer patients. The aim of this study was to determine the …
[HTML][HTML] Advances in landscape and related therapeutic targets of the prostate tumor microenvironment: Therapeutic targets of the prostate tumor microenvironment
The distinct tumor microenvironment (TME) of prostate cancer (PCa), which promotes tumor
proliferation and progression, consists of various stromal cells, immune cells, and a dense …
proliferation and progression, consists of various stromal cells, immune cells, and a dense …
Dissecting the immune suppressive human prostate tumor microenvironment via integrated single-cell and spatial transcriptomic analyses
The treatment of low-risk primary prostate cancer entails active surveillance only, while high-
risk disease requires multimodal treatment including surgery, radiation therapy, and …
risk disease requires multimodal treatment including surgery, radiation therapy, and …
Immune cell analyses of the tumor microenvironment in prostate cancer highlight infiltrating regulatory T cells and macrophages as adverse prognostic factors
LB Andersen, M Nørgaard, M Rasmussen… - The Journal of …, 2021 - Wiley Online Library
Improved risk stratification is needed for patients with localized prostate cancer. This study
characterized and assessed the prognostic potential of distinct immune cell infiltration …
characterized and assessed the prognostic potential of distinct immune cell infiltration …
Targeting HIC1/TGF-β axis-shaped prostate cancer microenvironment restrains its progression
T Wu, W Wang, G Shi, M Hao, Y Wang, M Yao… - Cell Death & …, 2022 - nature.com
Prostate cancer (PCa) is a malignant tumor that seriously threatens men's health worldwide.
Recently, stromal cells in the tumor microenvironment (TME) have been reported to …
Recently, stromal cells in the tumor microenvironment (TME) have been reported to …