Design and optimization of coin-shaped microreactor chips for PET radiopharmaceutical synthesis
AM Elizarov, RM Van Dam, YS Shin… - Journal of Nuclear …, 2010 - Soc Nuclear Med
An integrated elastomeric microfluidic device, with a footprint the size of a postage stamp,
has been designed and optimized for multistep radiosynthesis of PET tracers. Methods: The …
has been designed and optimized for multistep radiosynthesis of PET tracers. Methods: The …
[PDF][PDF] Automated PET radiosyntheses using microfluidic devices
CJ Steel, AT O'brien, SK Luthra… - Journal of Labelled …, 2007 - academia.edu
Microfluidic devices can be used to achieve rapid synthesis times whilst providing a highly
controlled reaction environment. These factors, in conjunction with their small size and …
controlled reaction environment. These factors, in conjunction with their small size and …
Microfluidic technology for PET radiochemistry
JM Gillies, C Prenant, GN Chimon, GJ Smethurst… - Applied radiation and …, 2006 - Elsevier
This paper describes the first application of a microfabricated reaction system to positron
emission tomography (PET) radiochemistry. We have applied microfluidic technology to …
emission tomography (PET) radiochemistry. We have applied microfluidic technology to …
Radiochemistry on chip: towards dose-on-demand synthesis of PET radiopharmaceuticals
We have developed an integrated microfluidic platform for producing 2-[18F]-fluoro-2-deoxy-
D-glucose (18F-FDG) in continuous flow from a single bolus of radioactive isotope solution …
D-glucose (18F-FDG) in continuous flow from a single bolus of radioactive isotope solution …
Batch-reactor microfluidic device: first human use of a microfluidically produced PET radiotracer
A Lebedev, R Miraghaie, K Kotta, CE Ball, J Zhang… - Lab on a Chip, 2013 - pubs.rsc.org
The very first microfluidic device used for the production of 18F-labeled tracers for clinical
research is reported along with the first human Positron Emission Tomography scan …
research is reported along with the first human Positron Emission Tomography scan …
[HTML][HTML] Economical droplet-based microfluidic production of [18F]FET and [18F]Florbetaben suitable for human use
Current equipment and methods for preparation of radiopharmaceuticals for positron
emission tomography (PET) are expensive and best suited for large-scale multi-doses …
emission tomography (PET) are expensive and best suited for large-scale multi-doses …
Dose-on-demand production of diverse 18F-radiotracers for preclinical applications using a continuous flow microfluidic system
Introduction The production of 18 F-radiotracers using continuous flow microfluidics is under-
utilized due to perceived equipment limitations. We describe the dose-on-demand principle …
utilized due to perceived equipment limitations. We describe the dose-on-demand principle …
Microreactors for radiopharmaceutical synthesis
AM Elizarov - Lab on a Chip, 2009 - pubs.rsc.org
Multiple advantages of microfluidics have been demonstrated in the area of organic
synthesis. However, only a limited number of them have found applications in …
synthesis. However, only a limited number of them have found applications in …
Recent Advances in Microfluidic Devices for the Radiosynthesis of PET‐imaging Probes
H Elkawad, Y Xu, M Tian, C Jin… - Chemistry–An Asian …, 2022 - Wiley Online Library
In order to accommodate the growing demand for positron emission tomography (PET), it
will be necessary to create innovative radiochemical and engineering technologies to …
will be necessary to create innovative radiochemical and engineering technologies to …
Fully automated production of diverse 18F-labeled PET tracers on the ELIXYS multireactor radiosynthesizer without hardware modification
Fully automated radiosynthesizers are continuing to be developed to meet the growing need
for the reliable production of PET tracers made under current good manufacturing practice …
for the reliable production of PET tracers made under current good manufacturing practice …