Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

N Kato, M Loh, F Takeuchi, N Verweij, X Wang… - Nature …, 2015 - nature.com
We carried out a trans-ancestry genome-wide association and replication study of blood
pressure phenotypes among up to 320,251 individuals of East Asian, European and South …

[PDF][PDF] DNA methylation analysis identifies loci for blood pressure regulation

MA Richard, T Huan, S Ligthart, R Gondalia… - The American Journal of …, 2017 - cell.com
Genome-wide association studies have identified hundreds of genetic variants associated
with blood pressure (BP), but sequence variation accounts for a small fraction of the …

Trans-ethnic association study of blood pressure determinants in over 750,000 individuals

A Giri, JN Hellwege, JM Keaton, J Park, C Qiu… - Nature …, 2019 - nature.com
In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure
to identify genes, tissues, phenomes and medication contexts of blood pressure …

Genome-wide association study identifies eight loci associated with blood pressure

C Newton-Cheh, T Johnson, V Gateva, MD Tobin… - Nature …, 2009 - nature.com
Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide.
To date, identification of common genetic variants influencing blood pressure has proven …

Associations between high blood pressure and DNA methylation

N Kazmi, HR Elliott, K Burrows, T Tillin, AD Hughes… - PloS one, 2020 - journals.plos.org
Background High blood pressure is a major risk factor for cardiovascular disease and is
influenced by both environmental and genetic factors. Epigenetic processes including DNA …

Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation

TJ Hoffmann, GB Ehret, P Nandakumar, D Ranatunga… - Nature …, 2017 - nature.com
Longitudinal electronic health records on 99,785 Genetic Epidemiology Research on Adult
Health and Aging (GERA) cohort individuals provided 1,342,814 systolic and diastolic blood …

Identification, heritability, and relation with gene expression of novel DNA methylation loci for blood pressure

Y Huang, M Ollikainen, M Muniandy, T Zhang… - …, 2020 - Am Heart Assoc
We conducted an epigenome-wide association study meta-analysis on blood pressure (BP)
in 4820 individuals of European and African ancestry aged 14 to 69. Genome-wide DNA …

Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians

N Kato, F Takeuchi, Y Tabara, TN Kelly, MJ Go, X Sim… - Nature …, 2011 - nature.com
We conducted a meta-analysis of genome-wide association studies of systolic (SBP) and
diastolic (DBP) blood pressure in 19,608 subjects of east Asian ancestry from the AGEN-BP …

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

E Evangelou, HR Warren, D Mosen-Ansorena… - Nature …, 2018 - nature.com
High blood pressure is a highly heritable and modifiable risk factor for cardiovascular
disease. We report the largest genetic association study of blood pressure traits (systolic …

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

GB Ehret, T Ferreira, DI Chasman, AU Jackson… - Nature …, 2016 - nature.com
To dissect the genetic architecture of blood pressure and assess effects on target organ
damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 …