Restricting the intake of calories has been practiced as a method for increasing both the
length and quality of life for over 500years. Experimental work confirming the success of this …

To date, the only intervention that has consistently been shown to slow the rate of aging, and
to increase mean and maximum lifespan in short-lived species, is life-long calorie restriction …

Caloric restriction (CR) is the only experimental nongenetic paradigm known to increase
lifespan. It has broad applicability and extends the life of most species through a retardation …

The diet known as calorie restriction (CR) is the most reproducible way to extend the
lifespan of mammals. Many of the early hypotheses to explain this effect were based on it …

Caloric restriction (CR), reduced protein, methionine, or tryptophan diets; and reduced
insulin and/or IGFI intracellular signaling can extend mean and/or maximum lifespan and …

Calorie restriction (CR), which usually refers to a 20–40% reduction in calorie intake, can
effectively prolong lifespan preventing most age‐associated diseases in several species …

For almost 70 years, calorie restriction has been known to extend life span. Despite the
extensive physiological characterization of this dietary regimen, the molecular basis for the …

Underlying the importance of research on the biology of aging is the fact that many nations
face the demographic reality of a rapidly aging populace and the looming healthcare …

Calorie restriction (CR), a nutritional intervention of reduced energy intake but with adequate
nutrition, has been shown to extend healthspan and lifespan in rodent and primate models …

Calorie restriction (CR) promotes healthy ageing in diverse species. Recently, it has been
shown that fasting for a portion of each day has metabolic benefits and promotes lifespan …