Current status and perspective biomarkers in AFP negative HCC: towards screening for and diagnosing hepatocellular carcinoma at an earlier stage

P Luo, S Wu, Y Yu, X Ming, S Li, X Zuo, J Tu - Pathology & Oncology …, 2020 - Springer
Hepatocellular carcinoma (HCC) is one of the most malignant cancer with high morbidity
and mortality which lead to a serious burden to society. AFP (alpha-fetoprotein) is the most …

New blood biomarkers for the diagnosis of AFP-negative hepatocellular carcinoma

T Wang, KH Zhang - Frontiers in Oncology, 2020 - frontiersin.org
An early diagnosis of hepatocellular carcinoma (HCC) followed by effective treatment is
currently critical for improving the prognosis and reducing the associated economic burden …

Accuracy of novel diagnostic biomarkers for hepatocellular carcinoma: An update for clinicians

P Reichl, W Mikulits - Oncology reports, 2016 - spandidos-publications.com
Hepatocellular carcinoma (HCC) is the most common liver malignancy and a leading cause
of cancer-related mortality worldwide. Accurate detection and differential diagnosis of early …

Evaluation of the combined application of AFP, AFP‐L3%, and DCP for hepatocellular carcinoma diagnosis: a meta‐analysis

X Wang, Y Zhang, N Yang, H He, X Tao… - BioMed research …, 2020 - Wiley Online Library
The role of α‐fetoprotein (AFP) in the surveillance and diagnosis of hepatocellular
carcinoma (HCC) has been questioned in recent years due to its low sensitivity and …

Biomarkers: evaluation of screening for and early diagnosis of hepatocellular carcinoma in Japan and China

P Song, J Gao, Y Inagaki, N Kokudo, K Hasegawa… - Liver cancer, 2013 - karger.com
Over the past few decades, the screening for and early diagnosis of hepatocellular
carcinoma (HCC) has attracted attention worldwide, and especially in Asian countries such …

[HTML][HTML] Present and future possibilities for early diagnosis of hepatocellular carcinoma

P Stefaniuk, J Cianciara… - World journal of …, 2010 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) represents the fifth most common cancer in the world, and
the third most frequent oncological cause of death. The incidence of HCC is on the increase …

Evaluation of individual and combined applications of serum biomarkers for diagnosis of hepatocellular carcinoma: a meta-analysis

B Hu, X Tian, J Sun, X Meng - International journal of molecular sciences, 2013 - mdpi.com
The clinical value of Serum alpha-fetoprotein (AFP) to detect early hepatocellular carcinoma
(HCC) has been questioned due to its low sensitivity and specificity found in recent years …

Comprehensive clinicopathologic study of alpha fetoprotein‐expression in a large cohort of patients with hepatocellular carcinoma

DA Ridder, A Weinmann… - … journal of cancer, 2022 - Wiley Online Library
Alpha fetoprotein (AFP) is the most widely used diagnostic and prognostic serum biomarker
for hepatocellular carcinoma (HCC). Despite its wide clinical use, a systematic …

[HTML][HTML] AFP-L3 for the diagnosis of early hepatocellular carcinoma: A meta-analysis

JM Zhou, T Wang, KH Zhang - Medicine, 2021 - journals.lww.com
Background: The present study aimed to systematically evaluate the diagnostic value of an
isoform of alpha-fetoprotein (AFP), AFP-L3, for early hepatocellular carcinoma (HCC) by a …

The GALAD scoring algorithm based on AFP, AFP-L3, and DCP significantly improves detection of BCLC early stage hepatocellular carcinoma

J Best, H Bilgi, D Heider, C Schotten… - Zeitschrift für …, 2016 - thieme-connect.com
Background: Hepatocellular carcinoma (HCC) is one of the leading causes of death in
cirrhotic patients worldwide. The detection rate for early stage HCC remains low despite …