Direct cellular reprogramming and inner ear regeneration

PJ Atkinson, GS Kim, AG Cheng - Expert opinion on biological …, 2019 - Taylor & Francis
Introduction: Sound is integral to communication and connects us to the world through
speech and music. Cochlear hair cells are essential for converting sounds into neural …

Approaches to treat sensorineural hearing loss by hair-cell regeneration: The current state of therapeutic developments and their potential impact on audiological …

AS Hinton, A Yang-Hood, AD Schrader… - Journal of the …, 2021 - thieme-connect.com
Sensorineural hearing loss (SNHL) is typically a permanent and often progressive condition
that is commonly attributed to sensory cell loss. All vertebrates except mammals can …

Stem cell-based hair cell regeneration and therapy in the inner ear

J Qi, W Huang, Y Lu, X Yang, Y Zhou, T Chen… - Neuroscience …, 2024 - Springer
Hearing loss has become increasingly prevalent and causes considerable disability, thus
gravely burdening the global economy. Irreversible loss of hair cells is a main cause of …

In vitro and in vivo models: What have we learnt about inner ear regeneration and treatment for hearing loss?

MP Lee, J Waldhaus - Molecular and Cellular Neuroscience, 2022 - Elsevier
The sensory cells of the inner ear, called hair cells, do not regenerate spontaneously and
therefore, hair cell loss and subsequent hearing loss are permanent in humans. Conversely …

Generation of inner ear hair cells by direct lineage conversion of primary somatic cells

L Menendez, T Trecek, S Gopalakrishnan, L Tao… - elife, 2020 - elifesciences.org
The mechanoreceptive sensory hair cells in the inner ear are selectively vulnerable to
numerous genetic and environmental insults. In mammals, hair cells lack regenerative …

Comparing sensory organs to define the path for hair cell regeneration

N Denans, S Baek, T Piotrowski - Annual review of cell and …, 2019 - annualreviews.org
Deafness or hearing deficits are debilitating conditions. They are often caused by loss of
sensory hair cells or defects in their function. In contrast to mammals, nonmammalian …

Concise review: regeneration in mammalian cochlea hair cells: help from supporting cells transdifferentiation

B Franco, B Malgrange - Stem Cells, 2017 - academic.oup.com
It is commonly assumed that mammalian cochlear cells do not regenerate. Therefore, if hair
cells are lost following an injury, no recovery could occur. However, during the first postnatal …

Hair cell regeneration

ASB Edge, ZY Chen - Current opinion in neurobiology, 2008 - Elsevier
The mammalian inner ear largely lacks the capacity to regenerate hair cells, the sensory
cells required for hearing and balance. Recent studies in both lower vertebrates and …

Insights into the molecular mechanisms regulating mammalian hair cell regeneration

Z Hu, A Singh, II Dennis Bojrab… - Current Opinion in …, 2021 - journals.lww.com
Insights into the molecular mechanisms regulating mammalian... : Current Opinion in
Otolaryngology & Head and Neck Surgery Insights into the molecular mechanisms …

Hair cell regeneration

Y Chen, S Zhang, R Chai, H Li - Hearing loss: Mechanisms, prevention …, 2019 - Springer
Cochlear hair cells are mechanoreceptors of the auditory system and cannot spontaneously
regenerate in adult mammals; thus hearing loss due to hair cell damage is permanent. In …