Direct cellular reprogramming and inner ear regeneration
Introduction: Sound is integral to communication and connects us to the world through
speech and music. Cochlear hair cells are essential for converting sounds into neural …
speech and music. Cochlear hair cells are essential for converting sounds into neural …
Approaches to treat sensorineural hearing loss by hair-cell regeneration: The current state of therapeutic developments and their potential impact on audiological …
AS Hinton, A Yang-Hood, AD Schrader… - Journal of the …, 2021 - thieme-connect.com
Sensorineural hearing loss (SNHL) is typically a permanent and often progressive condition
that is commonly attributed to sensory cell loss. All vertebrates except mammals can …
that is commonly attributed to sensory cell loss. All vertebrates except mammals can …
Stem cell-based hair cell regeneration and therapy in the inner ear
J Qi, W Huang, Y Lu, X Yang, Y Zhou, T Chen… - Neuroscience …, 2024 - Springer
Hearing loss has become increasingly prevalent and causes considerable disability, thus
gravely burdening the global economy. Irreversible loss of hair cells is a main cause of …
gravely burdening the global economy. Irreversible loss of hair cells is a main cause of …
In vitro and in vivo models: What have we learnt about inner ear regeneration and treatment for hearing loss?
MP Lee, J Waldhaus - Molecular and Cellular Neuroscience, 2022 - Elsevier
The sensory cells of the inner ear, called hair cells, do not regenerate spontaneously and
therefore, hair cell loss and subsequent hearing loss are permanent in humans. Conversely …
therefore, hair cell loss and subsequent hearing loss are permanent in humans. Conversely …
Generation of inner ear hair cells by direct lineage conversion of primary somatic cells
L Menendez, T Trecek, S Gopalakrishnan, L Tao… - elife, 2020 - elifesciences.org
The mechanoreceptive sensory hair cells in the inner ear are selectively vulnerable to
numerous genetic and environmental insults. In mammals, hair cells lack regenerative …
numerous genetic and environmental insults. In mammals, hair cells lack regenerative …
Comparing sensory organs to define the path for hair cell regeneration
Deafness or hearing deficits are debilitating conditions. They are often caused by loss of
sensory hair cells or defects in their function. In contrast to mammals, nonmammalian …
sensory hair cells or defects in their function. In contrast to mammals, nonmammalian …
Concise review: regeneration in mammalian cochlea hair cells: help from supporting cells transdifferentiation
B Franco, B Malgrange - Stem Cells, 2017 - academic.oup.com
It is commonly assumed that mammalian cochlear cells do not regenerate. Therefore, if hair
cells are lost following an injury, no recovery could occur. However, during the first postnatal …
cells are lost following an injury, no recovery could occur. However, during the first postnatal …
Hair cell regeneration
ASB Edge, ZY Chen - Current opinion in neurobiology, 2008 - Elsevier
The mammalian inner ear largely lacks the capacity to regenerate hair cells, the sensory
cells required for hearing and balance. Recent studies in both lower vertebrates and …
cells required for hearing and balance. Recent studies in both lower vertebrates and …
Insights into the molecular mechanisms regulating mammalian hair cell regeneration
Z Hu, A Singh, II Dennis Bojrab… - Current Opinion in …, 2021 - journals.lww.com
Insights into the molecular mechanisms regulating mammalian... : Current Opinion in
Otolaryngology & Head and Neck Surgery Insights into the molecular mechanisms …
Otolaryngology & Head and Neck Surgery Insights into the molecular mechanisms …
Hair cell regeneration
Y Chen, S Zhang, R Chai, H Li - Hearing loss: Mechanisms, prevention …, 2019 - Springer
Cochlear hair cells are mechanoreceptors of the auditory system and cannot spontaneously
regenerate in adult mammals; thus hearing loss due to hair cell damage is permanent. In …
regenerate in adult mammals; thus hearing loss due to hair cell damage is permanent. In …