Background: B-1a B cells and gut secretory IgA (SIgA) are absent in asplenic mice. Human
immunoglobulin M (IgM) memory B cells, which are functionally equivalent to mouse B-1a B …

OBJECTIVES IgM memory B cells that are responsible for the protection against infections
by encapsulated bacteria, require the spleen for their generation and/or survival. Since the …

Next to conventional B cells (or B‐2 cells), peritoneal B‐1 cells have been shown to
contribute significantly to the production of IgA‐secreting plasma cells in the gut. Evidence …

Secretory immunoglobulin A (SIgA) enhances host-microbiota symbiosis, whereas SIgM
remains poorly understood. We found that gut IgM+ plasma cells (PCs) were more abundant …

Abstract Objective Selective IgA deficiency (sIgAD) is the most common primary
immunodeficiency in Western countries. Patients can suffer from recurrent infections and …

It is unclear why selective deficiency in secreted (s) IgM causes Ab-mediated autoimmunity.
We demonstrate that sIgM is required for normal B cell development and selection. The …

B1 cells are a significant source of natural serum IgM, thereby serving as a first line of
defense against systemic bacterial and viral infections. They can migrate to the intestinal …

Objective Although immunoglobulin A (IgA) is abundantly expressed in the gut and known to
be an important component of mucosal barriers against luminal pathogens, its precise …

Antibody-secreting cells (ASCs) lodging in the mucosa of the small intestine are derived
from activated B cells that are thought to arise in gut-associated lymphoid tissues (GALT) …

The gut is the major site of antibody production in humans. The most abundant isotype
produced is IgA, but the importance of IgA has been questioned. On the one hand, in IgA …