The tumor microenvironment consists of tumor cells, extracellular matrix, blood vessels, and
non-tumor cells such as fibroblasts and immune cells. Crosstalk among components of this …

Signal transducer and activator of transcription (STAT) 1 is part of the Janus kinase
(JAK)/STAT signalling cascade and is best known for its essential role in mediating …

The first STAT family member, STAT1, is an essential component of interferon (IFN)-
signaling, which mediates several cellular functions in response to stimulation by cytokines …

STAT proteins and their mechanisms of signaling were originally defined largely in the
context of normal interferon signaling, where they have been shown to have specific roles in …

While he is considered transcription STAT3 as promotes factors an oncogene, STAT1 cell
survival/proliferation, STAT1 and STAT3 enhances appear inflammation to motility play …

STAT1 is activated by IFNs and other cell signals. Following activation, STAT1 is
translocated to the nuclei and activates transcription of IFN-stimulated genes. Although the …

Signal transducer and activator of transcription (STAT2) is a member of the STAT family that
plays an essential role in immune responses to extracellular and intracellular stimuli …

The transcription factors STAT1 and STAT3 appear to play opposite roles in tumorigenesis.
While STAT3 promotes cell survival/proliferation, motility and immune tolerance and is …

Intercellular communication between tumor cells, immune cells and the stroma characterises
the tumor microenvironment, which is instrumental for establishing the ecological niche that …

The role of STAT2 in mediating the antigrowth effects of type I interferon (IFN) is well‐
documented in vitro. Yet evidence of IFN‐activated STAT2 as having tumor suppressor …