A road map for understanding molecular and genetic determinants of osteoporosis

TL Yang, H Shen, A Liu, SS Dong, L Zhang… - Nature Reviews …, 2020 - nature.com
Osteoporosis is a highly prevalent disorder characterized by low bone mineral density and
an increased risk of fracture, termed osteoporotic fracture. Notably, bone mineral density …

Osteoporosis and bone mass disorders: from gene pathways to treatments

F Rivadeneira, O Mäkitie - Trends in Endocrinology & Metabolism, 2016 - cell.com
Genomic technologies have evolved rapidly contributing to the understanding of diseases.
Genome-wide association studies (GWAS) and whole-exome sequencing have aided the …

Genetics of osteoporosis from genome-wide association studies: advances and challenges

JB Richards, HF Zheng, TD Spector - Nature Reviews Genetics, 2012 - nature.com
Osteoporosis is among the most common and costly diseases and is increasing in
prevalence owing to the ageing of our global population. Clinically defined largely through …

Multistage genome-wide association meta-analyses identified two new loci for bone mineral density

L Zhang, HJ Choi, K Estrada, PJ Leo, J Li… - Human molecular …, 2014 - academic.oup.com
Aiming to identify novel genetic variants and to confirm previously identified genetic variants
associated with bone mineral density (BMD), we conducted a three-stage genome-wide …

Genetics of osteoporosis

QY Huang, AWC Kung - Molecular Genetics and Metabolism, 2006 - Elsevier
Osteoporosis is a common disease with a strong genetic component. In recent years, some
progress has been made in understanding the genetic basis of osteoporosis. Genetic factors …

Molecular genetic studies of gene identification for osteoporosis: the 2009 update

XH Xu, SS Dong, Y Guo, TL Yang, SF Lei… - Endocrine …, 2010 - academic.oup.com
Osteoporosis is a complex human disease that results in increased susceptibility to fragility
fractures. It can be phenotypically characterized using several traits, including bone mineral …

Searching for osteoporosis genes in the post-genome era: progress and challenges

QY Huang, RR Recker, HW Deng - Osteoporosis International, 2003 - Springer
Osteoporosis is a common skeletal disease characterized by low bone mineral density
(BMD), deterioration of bone microarchitecture and increased fracture risk. It is a complex …

[HTML][HTML] An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related …

YH Hsu, MC Zillikens, SG Wilson, CR Farber… - PLoS …, 2010 - journals.plos.org
Osteoporosis is a complex disorder and commonly leads to fractures in elderly persons.
Genome-wide association studies (GWAS) have become an unbiased approach to identify …

Novel insights into the complex architecture of osteoporosis molecular genetics

FA Saad - Annals of the New York Academy of Sciences, 2020 - Wiley Online Library
Osteoporosis is a prevalent osteodegenerative disease and silent killer linked to a decrease
in bone mass and decline of bone microarchitecture, due to impaired bone matrix …

Genetics of osteoporosis: accelerating pace in gene identification and validation

WF Li, SX Hou, B Yu, MM Li, C Férec, JM Chen - Human genetics, 2010 - Springer
Osteoporosis is characterized by low bone mineral density and structural deterioration of
bone tissue, leading to an increased risk of fractures. It is the most common metabolic bone …