The design of glycoclusters, glycodendrimers, glycopolymers and other complex
glycostructures that mimic the multivalent carbohydrate display on the cell surface is of …

Conspectus The limited availability of structurally well-defined diverse glycans remains a
major obstacle for deciphering biological functions as well as biomedical applications of …

Conspectus Carbohydrates are called the third chain of life. Carbohydrates participate in
many important biochemical functions in living species, and the biological information …

Glycans and glycosylated biomolecules are directly involved in almost every biological
process as well as the etiology of most major diseases. Hence, glycoscience knowledge is …

This JACS Select issue highlights current and emerging areas of research at the chemistry−
glycobiology interface and illustrates how chemical and physical approaches are being …

The ability to reconstitute natural glycosylation pathways or prototype entirely new ones from
scratch is hampered by the limited availability of functional glycoenzymes, many of which …

A robust platform for facile defined glycan synthesis does not exist. Yet the need for such
technology has never been greater as researchers seek to understand the full scope of …

Highlights•Large carbohydrate-containing molecules are often needed for biological
studies.•Chemical and chemoenzymatic methods exist for the preparation of large …

The challenge of engineering glycosylation has been confronted by synthetic chemists,
biochemists and cell biologists, each with the primary goal of optimizing glycoconjugates for …

The importance of post-translational glycosylation in protein structure and function has
gained significant clinical relevance recently. The latest developments in glycobiology …