Centromeres are built on repetitive DNA sequences (CenDNA) and a specific chromatin
enriched with the histone H3 variant CENP‐A, the epigenetic mark that identifies centromere …

Centromeric repetitive DNA is the largest missing piece of the Human Genome Project.
Rather than being necessary or sufficient to specify the site of mitotic spindle attachment to …

Centromere assembly and propagation is governed by genetic and epigenetic mechanisms.
A centromere-specific histone H3 variant, CENP-A is strongly favored as the epigenetic mark …

Chromatin assembled with the histone H3 variant CENP-A is the heritable epigenetic
determinant of human centromere identity. Using genome-wide mapping and reference …

CENP-A is the histone H3 variant necessary to specify the location of all eukaryotic
centromeres via its CENP-A targeting domain and either one of its terminal regions. In …

The centromere is a chromatin region that serves as the spindle attachment point and directs
accurate inheritance of eukaryotic chromosomes during cell divisions. However, the …

The centromere is an essential functional domain responsible for the correct inheritance of
eukaryotic chromosomes during cell division. Eukaryotic centromeres include the highly …

The centromere is a specialized region on the chromosome that directs equal chromosome
segregation. Centromeres are usually not defined by DNA sequences alone. How …

The centromere—defined by the presence of nucleosomes containing the histone H3
variant, CENP-A—is the chromosomal locus required for the accurate segregation of …

Centromeres are essential chromosomal structures that mediate the accurate distribution of
genetic material during meiotic and mitotic cell divisions. In most organisms, centromeres …