[HTML][HTML] Role of N6-methyladenosine modification in central nervous system diseases and related therapeutic agents

J Lv, L Xing, X Zhong, K Li, M Liu, K Du - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Abstract N6-methyladenosine (m6A) is a ubiquitous mRNA modification in eukaryotes. m6A
occurs through the action of methyltransferases, demethylases, and methylation-binding …

m6A methylation: Critical roles in aging and neurological diseases

Y Fan, X Lv, Z Chen, Y Peng, M Zhang - Frontiers in Molecular …, 2023 - frontiersin.org
N6-methyladenosine (m6A) is the most abundant internal RNA modification in eukaryotic
cells, which participates in the functional regulation of various biological processes. It …

Dynamic N6-methyladenosine RNA methylation in brain and diseases

AM Shafik, EG Allen, P Jin - Epigenomics, 2020 - Taylor & Francis
N6-methyladenosine (m6A) is a dynamic RNA modification that regulates various aspects of
RNA metabolism and has been implicated in many biological processes and transitions …

N6-methyladenosine and neurological diseases

N Zhang, C Ding, Y Zuo, Y Peng, L Zuo - Molecular neurobiology, 2022 - Springer
Abstract N6-methyladenosine (m6A) is a dynamic reversible methylation modification of the
adenosine N6 position and is the most common chemical epigenetic modification among …

In Search of a Function for the N6-Methyladenosine in Epitranscriptome, Autophagy and Neurodegenerative Diseases

N Suga, Y Ikeda, S Yoshikawa, K Taniguchi… - Neurology …, 2023 - mdpi.com
Changes in epitranscriptome with N6-methyladenine (m6A) modification could be involved
in the development of multiple diseases, which might be a prevalent modification of …

The role and regulatory mechanism of m6A methylation in the nervous system

L Jiang, X Li, S Wang, Z Yuan, J Cheng - Frontiers in Genetics, 2022 - frontiersin.org
N6-methyladenosine (m6A) modification regulates RNA translation, splicing, transport,
localization, and stability at the post-transcriptional level. The m6A modification has been …

The progression of N6-methyladenosine study and its role in neuropsychiatric disorders

C Lei, Q Wang - International Journal of Molecular Sciences, 2022 - mdpi.com
Epitranscriptomic modifications can affect every aspect of RNA biology, including stability,
transport, splicing, and translation, participate in global intracellular mRNA metabolism, and …

Down-regulation of m6A mRNA methylation is involved in dopaminergic neuronal death

X Chen, C Yu, M Guo, X Zheng, S Ali… - ACS chemical …, 2019 - ACS Publications
N 6-Methyladenosine (m6A) is the most prevalent internal modification that occurs in the
mRNA of eukaryotes and plays a vital role in the post-transcriptional regulation. Recent …

m6A RNA methylation in brain injury and neurodegenerative disease

J Deng, X Chen, A Chen, X Zheng - Frontiers in Neurology, 2022 - frontiersin.org
N6-methyladenosine (m6A), the most prevalent post-transcriptional RNA modification
throughout the eukaryotic transcriptome, participates in diverse biophysiological processes …

New Insights on the Role of N6-Methyladenosine RNA Methylation in the Physiology and Pathology of the Nervous System

G Dermentzaki, F Lotti - Frontiers in Molecular Biosciences, 2020 - frontiersin.org
RNA modifications termed epitranscriptomics represent an additional layer of gene
regulation similar to epigenetic mechanisms operating on DNA. The dynamic nature and the …