Control of lymphocyte functions by gut microbiota-derived short-chain fatty acids

CH Kim - Cellular & molecular immunology, 2021 - nature.com
A mounting body of evidence indicates that dietary fiber (DF) metabolites produced by
commensal bacteria play essential roles in balancing the immune system. DF, considered …

[PDF][PDF] Gut microbiota-derived short-chain fatty acids, T cells, and inflammation

CH Kim, J Park, M Kim - Immune network, 2014 - synapse.koreamed.org
T cells are central players in the regulation of adaptive immunity and immune tolerance. In
the periphery, T cell differentiation for maturation and effector function is regulated by a …

Regulation of short-chain fatty acids in the immune system

X Liu, J Shao, YT Liao, LN Wang, Y Jia… - Frontiers in …, 2023 - frontiersin.org
A growing body of research suggests that short-chain fatty acids (SCFAs), metabolites
produced by intestinal symbiotic bacteria that ferment dietary fibers (DFs), play a crucial role …

The emerging role of microbiota-derived short-chain fatty acids in immunometabolism

SA Jasim, MJC Opulencia, AA Ramírez-Coronel… - International …, 2022 - Elsevier
The accumulating evidence revealed that microbiota plays a significant function in training,
function, and the induction of host immunity. Once this interaction (immune system …

Complex regulatory effects of gut microbial short-chain fatty acids on immune tolerance and autoimmunity

CH Kim - Cellular & molecular immunology, 2023 - nature.com
Immune tolerance deletes or suppresses autoreactive lymphocytes and is established at
multiple levels during the development, activation and effector phases of T and B cells …

Short chain fatty acids: key regulators of the local and systemic immune response in inflammatory diseases and infections

LM Ney, M Wipplinger, M Grossmann… - Open …, 2023 - royalsocietypublishing.org
The human intestinal microbiome substantially affects human health and resistance to
infections in its dynamic composition and varying release of microbial-derived metabolites …

Short‐chain fatty acids: Bacterial messengers modulating the immunometabolism of T cells

M Luu, A Visekruna - European Journal of Immunology, 2019 - Wiley Online Library
Short‐chain fatty acids (SCFAs) are mainly generated by bacterial fermentation of non‐
digestible carbohydrates such as dietary fiber. In the last decade, new investigations have …

Short-chain fatty acids: linking diet, the microbiome and immunity

ER Mann, YK Lam, HH Uhlig - Nature Reviews Immunology, 2024 - nature.com
The short-chain fatty acids (SCFAs) butyrate, propionate and acetate are microbial
metabolites and their availability in the gut and other organs is determined by environmental …

A major mechanism for immunomodulation: Dietary fibres and acid metabolites

L Xie, MJ Alam, FZ Marques, CR Mackay - Seminars in Immunology, 2023 - Elsevier
Diet and the gut microbiota have a profound influence on physiology and health, however,
mechanisms are still emerging. Here we outline several pathways that gut microbiota …

Regulation of CD4+ and CD8+ T Cell Biology by Short-Chain Fatty Acids and Its Relevance for Autoimmune Pathology

C Schiweck, S Edwin Thanarajah, M Aichholzer… - International Journal of …, 2022 - mdpi.com
The gut microbiota encodes a broad range of enzymes capable of synthetizing various
metabolites, some of which are still uncharacterized. One well-known class of microbiota …