Stromal cells generated in long-term cultures appear to follow a vascular smooth muscle
differentiation pathway. Such a pathway, comprising several steps hallmarked by the …

In human long-term marrow cultures connective tissue-forming stromal cells are an essential
cellular component of the adherent layer where granulomonocytic progenitors are …

About 40 years ago Friedenstein described stromal cells in the bone marrow that were
spindle shaped and proliferate to form colonies. These cells attach to plastic and are able to …

Evidence for the hypothesis that there are stromal stem cells present in the soft connective
tissues associated with marrow and bone surfaces that are able to give rise to a number of …

Bone marrow stromal cells are progenitors of skeletal tissue components such as bone,
cartilage, the hematopoiesis-supporting stroma, and adipocytes. In addition, they may be …

OBJECTIVES: To better understand the differentiation of stromal cells of the hematopoietic
microenvironment, we set out to characterize stromal cells from the different developmental …

The progenitors for cells of bone, cartilage, fat, and muscle are thought to be derived from
mesenchymal stem cells but despite extensive study of stromal cell differentiation, neither …

The precursors of bone, cartilage, fat and muscle cells are likely to be derived from more
primitive mesenchymal cells which exhibit some of the characteristics of stem cells. Despite …

The role of hematopoietic stem cells in blood cell development is reasonably understood,
whereas the identity and the function of bone marrow stromal cells are much less clear …

Multipotent mesenchymal stromal/stem cells (MSCs) reside in many human organs and
comprise heterogeneous population of cells with self‐renewal ability. These cells can be …