Pancreatic cancer proceeds from the accumulation of genetic mutations that arise in
precursor cells in the pancreas, including mutations in Kras and p53. The biological …

The MUC1 cytoplasmic tail (MUC1. CT) conducts signals from spatial and extracellular cues
(growth factor and cytokine stimulation) to evoke a reprogramming of the cellular …

Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal human cancers. The
incidence rate of PDA nearly matches its mortality rate and the best treatment till date is …

MUC1 is overexpressed and aberrantly glycosylated in more than 60% of pancreatic ductal
adenocarcinomas. The functional role of MUC1 in pancreatic cancer has yet to be fully …

The MUC4 mucin is a high molecular weight membrane-bound glycoprotein. It is aberrantly
expressed in pancreatic tumors and tumor cell lines with no detectable expression in the …

MUC4, a transmembrane mucin, is aberrantly expressed in pancreatic adenocarcinomas
while remaining undetectable in the normal pancreas. Recent studies have shown that the …

MUCs are glycoproteins with various roles in homeostasis and carcinogenesis. Among other
actions, MUC1 may inhibit cell–cell and cell–stroma interactions and function as a signal …

The DF3/MUC1 mucin-like transmembrane oncoprotein is overexpressed by most human
carcinomas. The MUC1 cytoplasmic domain (CD) binds directly to the Wnt effector, beta …

MUC4 is highly expressed in human pancreatic tumours and pancreatic tumour cell lines,
but is minimally or not expressed in normal pancreas or chronic pancreatitis. Here, we …

Objectives The aim of the present study was to characterize molecular targets for the
prevention/diagnosis of pancreatic cancer using a chemically induced hamster pancreatic …