Inhibiting HCMV pUL89-C Endonuclease with Metal-Binding Compounds: Miniperspective
Human cytomegalovirus (HCMV) infects individuals of all ages and establishes a lifelong
latency. Current antiviral drugs are suboptimal in efficacy and safety and ineffective against …
latency. Current antiviral drugs are suboptimal in efficacy and safety and ineffective against …
4, 5-Dihydroxypyrimidine methyl carboxylates, carboxylic acids, and carboxamides as inhibitors of human cytomegalovirus pUL89 endonuclease
T He, TC Edwards, J Xie, H Aihara… - Journal of medicinal …, 2022 - ACS Publications
Human cytomegalovirus (HCMV) terminase complex entails a metal-dependent
endonuclease at the C-terminus of pUL89 (pUL89-C). We report herein the design …
endonuclease at the C-terminus of pUL89 (pUL89-C). We report herein the design …
Metal binding 6-arylthio-3-hydroxypyrimidine-2, 4-diones inhibited human cytomegalovirus by targeting the pUL89 endonuclease of the terminase complex
L Wang, TC Edwards, RL Sahani, J Xie… - European journal of …, 2021 - Elsevier
The genome packaging of human cytomegalovirus (HCMV) requires a divalent metal-
dependent endonuclease activity localized to the C-terminus of pUL89 (pUL89-C), which is …
dependent endonuclease activity localized to the C-terminus of pUL89 (pUL89-C), which is …
Metal-chelating 3-hydroxypyrimidine-2, 4-diones inhibit human cytomegalovirus pUL89 endonuclease activity and virus replication
Human cytomegalovirus terminase complex cleaves the concatemeric genomic viral DNA
into unit lengths during genome packaging and particle assembly. Terminase complex …
into unit lengths during genome packaging and particle assembly. Terminase complex …
Hydroxypyridonecarboxylic acids as inhibitors of human cytomegalovirus pUL89 endonuclease
Human cytomegalovirus (HCMV) infection poses a major health threat to
immunocompromised individuals. Until recently, treatment of HCMV infection has relied …
immunocompromised individuals. Until recently, treatment of HCMV infection has relied …
Repurposing N-hydroxy thienopyrimidine-2, 4-diones (HtPD) as inhibitors of human cytomegalovirus pUL89 endonuclease: Synthesis and biological characterization
T He, TC Edwards, R Majima, E Jung, J Kankanala… - Bioorganic …, 2022 - Elsevier
The terminase complex of human cytomegalovirus (HCMV) is required for viral genome
packaging and cleavage. Critical to the terminase functions is a metal-dependent …
packaging and cleavage. Critical to the terminase functions is a metal-dependent …
8‐Hydroxy‐1, 6‐naphthyridine‐7‐carboxamides as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease
E Jung, R Majima, TC Edwards, R Soto‐Acosta… - …, 2022 - Wiley Online Library
Human cytomegalovirus (HCMV) replication requires a metal‐dependent endonuclease at
the C‐terminus of pUL89 (pUL89‐C) for viral genome packaging and cleavage. We have …
the C‐terminus of pUL89 (pUL89‐C) for viral genome packaging and cleavage. We have …
Inhibition of human cytomegalovirus pUL89 terminase subunit blocks virus replication and genome cleavage
The human cytomegalovirus terminase complex cleaves concatemeric genomic DNA into
unit lengths during genome packaging and particle assembly. This process is an attractive …
unit lengths during genome packaging and particle assembly. This process is an attractive …
Mutual interplay between the human cytomegalovirus terminase subunits pUL51, pUL56, and pUL89 promotes terminase complex formation
S Neuber, K Wagner, T Goldner, P Lischka… - Journal of …, 2017 - Am Soc Microbiol
Human cytomegalovirus (HCMV) genome encapsidation requires several essential viral
proteins, among them pUL56, pUL89, and the recently described pUL51, which constitute …
proteins, among them pUL56, pUL89, and the recently described pUL51, which constitute …
[HTML][HTML] Identification of Small Molecule Inhibitors of Human Cytomegalovirus pUL89 Endonuclease Using Integrated Computational Approaches
Replication of Human Cytomegalovirus (HCMV) requires the presence of a metal-
dependent endonuclease at the C-terminus of pUL89, in order to properly pack and cleave …
dependent endonuclease at the C-terminus of pUL89, in order to properly pack and cleave …