MDM2 integrates cellular respiration and apoptotic signaling through NDUFS1 and the mitochondrial network
Signaling diversity and subsequent complexity in higher eukaryotes is partially explained by
one gene encoding a polypeptide with multiple biochemical functions in different cellular …
one gene encoding a polypeptide with multiple biochemical functions in different cellular …
Mitochondrial MDM2 regulates respiratory complex I activity independently of p53
Accumulating evidence indicates that the MDM2 oncoprotein promotes tumorigenesis
beyond its canonical negative effects on the p53 tumor suppressor, but these p53 …
beyond its canonical negative effects on the p53 tumor suppressor, but these p53 …
Mitochondrial MDM4 (MDMX): an unpredicted role in the p53-mediated intrinsic apoptotic pathway
F Mancini, F Moretti - Cell cycle, 2009 - Taylor & Francis
P53 is a crucial regulator of cell response to DNA damage. MDM4 and MDM2 are the two
main negative regulators of p53 activity. Upon DNA damage, their constraint is released and …
main negative regulators of p53 activity. Upon DNA damage, their constraint is released and …
MDM4 (MDMX) localizes at the mitochondria and facilitates the p53‐mediated intrinsic‐apoptotic pathway
F Mancini, G Di Conza, M Pellegrino, C Rinaldo… - The EMBO …, 2009 - embopress.org
MDM4 is a key regulator of p53, whose biological activities depend on both transcriptional
activity and transcription‐independent mitochondrial functions. MDM4 binds to p53 and …
activity and transcription‐independent mitochondrial functions. MDM4 binds to p53 and …
Mitochondrial fission proteins regulate programmed cell death in yeast
Y Fannjiang, WC Cheng, SJ Lee, B Qi… - Genes & …, 2004 - genesdev.cshlp.org
The possibility that single-cell organisms undergo programmed cell death has been
questioned in part because they lack several key components of the mammalian cell death …
questioned in part because they lack several key components of the mammalian cell death …
Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster
The accumulation of dysfunctional mitochondria has been implicated in aging, but a deeper
understanding of mitochondrial dynamics and mitophagy during aging is missing. Here, we …
understanding of mitochondrial dynamics and mitophagy during aging is missing. Here, we …
Control of mitochondrial homeostasis by endocytic regulatory proteins
Mitochondria play essential roles in cellular energy processes, including ATP production,
control of reactive oxygen species (ROS) and apoptosis. While mitochondrial function is …
control of reactive oxygen species (ROS) and apoptosis. While mitochondrial function is …
MIEF1/2 function as adaptors to recruit Drp1 to mitochondria and regulate the association of Drp1 with Mff
Mitochondrial dynamics is a fundamental cellular process and recruitment of Drp1 to
mitochondria is an essential step in mitochondrial fission. Mff and MIEF1/2 (MiD51/49) serve …
mitochondria is an essential step in mitochondrial fission. Mff and MIEF1/2 (MiD51/49) serve …
The novel conserved mitochondrial inner-membrane protein MTGM regulates mitochondrial morphology and cell proliferation
Although several proteins involved in mediating mitochondrial division have been reported
in mammals, the mechanism of the fission machinery remains to be elucidated. Here, we …
in mammals, the mechanism of the fission machinery remains to be elucidated. Here, we …
SENP3-mediated deSUMOylation of Drp1 facilitates interaction with Mff to promote cell death
The GTPase dynamin-related protein 1 (Drp1) is essential for physiological and
pathophysiological mitochondrial fission. DeSUMOylation of Drp1 by the enzyme SENP3 …
pathophysiological mitochondrial fission. DeSUMOylation of Drp1 by the enzyme SENP3 …