Identification of BGN positive fibroblasts as a driving factor for colorectal cancer and development of its related prognostic model combined with machine learning
S Hu, Q Xiao, R Gao, J Qin, J Nie, Y Chen, J Lou… - BMC cancer, 2024 - Springer
Background Numerous studies have indicated that cancer-associated fibroblasts (CAFs)
play a crucial role in the progression of colorectal cancer (CRC). However, there are still …
play a crucial role in the progression of colorectal cancer (CRC). However, there are still …
Integrated single-cell and bulk RNA sequencing analysis identifies a cancer associated fibroblast-related signature for predicting prognosis and therapeutic responses …
H Zheng, H Liu, Y Ge, X Wang - Cancer cell international, 2021 - Springer
Abstract Background Cancer-associated fibroblasts (CAFs) contribute notably to colorectal
cancer (CRC) tumorigenesis, stiffness, angiogenesis, immunosuppression and metastasis …
cancer (CRC) tumorigenesis, stiffness, angiogenesis, immunosuppression and metastasis …
[HTML][HTML] A WGCNA-based cancer-associated fibroblast risk signature in colorectal cancer for prognosis and immunotherapy response
Y Lv, J Hu, W Zheng, L Shan, B Bai… - Translational Cancer …, 2023 - ncbi.nlm.nih.gov
Background Cancer-associated fibroblasts (CAFs) are notably involved in colorectal cancer
(CRC) tumorigenesis, progression, and treatment failure. In this article, we report the in silico …
(CRC) tumorigenesis, progression, and treatment failure. In this article, we report the in silico …
Cancer-associated fibroblast-related gene signatures predict survival and drug response in patients with colorectal cancer
L Zhang, C Xu, SH Wang, QW Ge, XW Wang… - Frontiers in …, 2022 - frontiersin.org
Background: Cancer-associated fibroblasts (CAFs) play an important role in the
tumorigenesis, immunosuppression and metastasis of colorectal cancer (CRC), and can …
tumorigenesis, immunosuppression and metastasis of colorectal cancer (CRC), and can …
A comprehensive multi-omics analysis identifies a robust scoring system for cancer-associated fibroblasts and intervention targets in colorectal cancer
F Wang, Z Li, T Xu, Q Zhang, T Ma, S Li… - Journal of Cancer …, 2024 - Springer
Background Cancer-associated fibroblasts (CAF) play a critical role in promoting tumor
growth, metastasis, and immune evasion. While numerous studies have investigated CAF …
growth, metastasis, and immune evasion. While numerous studies have investigated CAF …
Cancer-associated fibroblasts impact the clinical outcome and treatment response in colorectal cancer via immune system modulation: a comprehensive genome …
Y Chen, Z Yu, M Lv, Z Cai, Y Zou, P Lan, X Wu… - Molecular Medicine, 2021 - Springer
Abstract Background Cancer-associated fibroblasts (CAFs) in the tumour microenvironment
are associated with poor prognosis and chemoresistance in multiple solid tumours …
are associated with poor prognosis and chemoresistance in multiple solid tumours …
Systematic identification of cancer-associated-fibroblast-derived genes in patients with colorectal cancer based on single-cell sequencing and transcriptomics
J Zhao, Y Chen - Frontiers in Immunology, 2022 - frontiersin.org
Colorectal cancer (CRC) has a high incidence rate and poor prognosis, and the available
treatment approaches have limited therapeutic benefits. Therefore, understanding the …
treatment approaches have limited therapeutic benefits. Therefore, understanding the …
Cancer‐Associated Fibroblast Risk Model for Prediction of Colorectal Carcinoma Prognosis and Therapeutic Responses
Y Wang, Z Chen, G Zhao, Q Li - Mediators of Inflammation, 2023 - Wiley Online Library
Colorectal carcinoma (CRC) is a malignant tumor of the digestive system. Cancer‐
associated fibroblasts (CAFs) are important cellular elements in the tumor microenvironment …
associated fibroblasts (CAFs) are important cellular elements in the tumor microenvironment …
Prognostic and predictive value of BGN in colon cancer outcomes and response to immunotherapy
ZX He, SB Zhao, X Fang, JF E, HY Fu, YH Song… - Frontiers in …, 2022 - frontiersin.org
Background Colon cancer is one of the most frequent malignancies and causes high
mortality worldwide. Exploring the tumor-immune interactions in the tumor microenvironment …
mortality worldwide. Exploring the tumor-immune interactions in the tumor microenvironment …
Cancer-associated fibroblasts of colorectal cancer and their markers: updates, challenges and translational outlook
Accumulation of cancer-associated fibroblasts (CAFs) in the tumor microenvironment is
associated with poor prognosis and recurrence of colorectal cancer (CRC). Despite their …
associated with poor prognosis and recurrence of colorectal cancer (CRC). Despite their …
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