Defects in the light-evoked responses of the retina occur early in the sequalae of diabetic
retinopathy (DR). These defects, identified through the electroretinogram (ERG), represent …

Hyperglycemia is a key determinant for development of diabetic retinopathy (DR).
Inadequate glycemic control exacerbates retinopathy, while normalization of glucose levels …

High blood glucose results in high glucose levels in retina, because GLUT1, the sole
glucose transporter between blood and retina, transports more glucose when blood glucose …

The retina is one of the most metabolically active tissues in the body and utilizes glucose to
produce energy and intermediates required for daily renewal of photoreceptor cell outer …

The pathological changes in the retinal microvasculature characteristic of diabetic
retinopathy (DR) are the result of chronic exposure to elevated blood glucose. Since glucose …

Purpose: To investigate the effect of chronic hyperglycemia on the levels of the glucose
transporter GLUT1 in retina and its ubiquitinylation. Methods: Two diabetic animal models …

The early pathogenetic mechanism of diabetic retinopathy (DR) and its treatment remain
unclear. Therefore, we investigated the early pathogenic alterations in DR using …

Aims/hypothesis Diabetic retinopathy is a major complication of type 2 diabetes and the
leading cause of blindness in adults of working age. Neuronal defects are known to occur …

Diabetic retinopathy (DR) is a leading cause of blindness in working age adults. DR has non-
proliferative stages, characterized in part by retinal neuroinflammation and ischemia, and …

Photoreceptors consume glucose supplied by the choriocapillaris to support
phototransduction and outer segment (OS) renewal. Reduced glucose supply underlies …