Motivation: Protein insolubility is a major obstacle for many experimental studies. A
sequence-based prediction method able to accurately predict the propensity of a protein to …

Motivation Protein solubility plays a vital role in pharmaceutical research and production
yield. For a given protein, the extent of its solubility can represent the quality of its function …

Here we introduce cc SOL omics, a webserver for large-scale calculations of protein
solubility. Our method allows (i) proteome-wide predictions;(ii) identification of soluble …

Motivation The heterologous expression of recombinant protein requires host cells, such as
Escherichiacoli, and the solubility of protein greatly affects the protein yield. A novel and …

Motivation Protein solubility can be a decisive factor in both research and production
efficiency, and in silico sequence-based predictors that can accurately estimate solubility …

Motivation: Obtaining soluble proteins in sufficient concentrations is a recurring limiting
factor in various experimental studies. Solubility is an individual trait of proteins which, under …

Motivation Protein solubility is an important property in industrial and therapeutic
applications. Prediction is a challenge, despite a growing understanding of the relevant …

Many fields of science and industry depend on efficient production of active protein using
heterologous expression in Escherichia coli. The solubility of proteins upon expression is …

Motivation Recombinant protein production is a widely used technique in the biotechnology
and biomedical industries, yet only a quarter of target proteins are soluble and can therefore …

Motivation The solubility of a protein is often decisive for its proper functioning. Lack of
solubility is a major bottleneck in high-throughput structural genomic studies and in high …