Recent studies are beginning to paint a clear and consistent picture of the impairments in
psychological and cognitive competencies that are associated with microdeletions in …

Over the last fifteen years it has become established that 22q11. 2 deletion syndrome
(22q11DS) is a true genetic risk factor for schizophrenia. Carriers of deletions in …

Abstract 22q11. 2 Deletion syndrome has become an important model for understanding the
pathophysiology of neurodevelopmental conditions, particularly schizophrenia which …

Abstract 22q11. 2 Deletion Syndrome (22q11. 2DS) is a common microdeletion syndrome
with congenital and late-onset features. Testing for the genomic content of copy number …

Abstract The 22q11. 2 deletion (22q11DS) is a common chromosomal microdeletion and a
potent risk factor for psychotic illness. Prior studies reported widespread cortical changes in …

Abstract Introduction 22q11. 2 deletion syndrome (22q11DS) represents one of the largest
known genetic risk factors for psychosis, yet the neurobiological mechanisms underlying …

Background Genome-wide scans have uncovered rare copy number variants conferring
high risk of psychiatric disorders. The 15q13. 3 microdeletion is associated with a …

Rare copy number variants contribute significantly to the risk for schizophrenia, with the
22q11. 2 locus consistently implicated. Individuals with the 22q11. 2 deletion syndrome …

Abstract 22q11. 2 Deletion Syndrome (22q11DS) is the most common genetic microdeletion
syndrome affecting humans. The syndrome is associated with general cognitive impairments …

We used a mouse model of the schizophrenia-predisposing 22q11. 2 microdeletion to
evaluate how this genetic lesion affects cortical neural circuits at the synaptic, cellular, and …