DNA damage-inducible transcript 4 (DDIT4) mediates methamphetamine-induced autophagy and apoptosis through mTOR signaling pathway in cardiomyocytes

R Chen, B Wang, L Chen, D Cai, B Li, C Chen… - Toxicology and applied …, 2016 - Elsevier
Methamphetamine (METH) is an amphetamine-like psychostimulant that is commonly
abused. Previous studies have shown that METH can induce damages to the nervous …

Effects of DDIT4 in methamphetamine-induced autophagy and apoptosis in dopaminergic neurons

B Li, R Chen, L Chen, P Qiu, X Ai, E Huang… - Molecular …, 2017 - Springer
Methamphetamine (METH) is an illicit psychoactive drug that can cause a variety of
detrimental effects to the nervous system, especially dopaminergic pathways. We …

Involvement of C/EBPβ-related signaling pathway in methamphetamine-induced neuronal autophagy and apoptosis

E Huang, H Huang, T Guan, C Liu, D Qu, Y Xu, J Yang… - Toxicology Letters, 2019 - Elsevier
Methamphetamine (METH) is a widely abused illicit psychoactive drug. Our previous study
has shown that CCAAT-enhancer binding protein β (C/EBPβ) is an important regulator in …

DDiT4L promotes autophagy and inhibits pathological cardiac hypertrophy in response to stress

B Simonson, V Subramanya, MC Chan, A Zhang… - Science …, 2017 - science.org
Physiological cardiac hypertrophy, in response to stimuli such as exercise, is considered
adaptive and beneficial. In contrast, pathological cardiac hypertrophy that arises in response …

Dexmedetomidine protects against lidocaine-induced neurotoxicity through SIRT1 downregulation-mediated activation of FOXO3a

LN Zheng, FQ Guo, ZS Li, Z Wang… - Human & …, 2020 - journals.sagepub.com
Lidocaine, a typical local anesthetic, has been shown to directly induce neurotoxicity in
clinical settings. Dexmedetomidine (DEX) is an alpha-2-adrenoreceptor agonist that has …

CDK5-mediated tau accumulation triggers methamphetamine-induced neuronal apoptosis via endoplasmic reticulum-associated degradation pathway

N Xiao, F Zhang, B Zhu, C Liu, Z Lin, H Wang, WB Xie - Toxicology letters, 2018 - Elsevier
Overexposure to methamphetamine (METH) causes apoptosis in a number of cell types,
particularly neuronal cells. However, the underlying mechanisms of METH-induced …

Knockdown of Mtfp1 can minimize doxorubicin cardiotoxicity by inhibiting Dnm1l‐mediated mitochondrial fission

LHH Aung, R Li, BS Prabhakar… - Journal of cellular and …, 2017 - Wiley Online Library
The long‐term usage of doxorubicin (DOX) is largely limited due to the development of
severe cardiomyopathy. Many studies indicate that DOX‐induced cardiac injury is related to …

Inhibition of Drp1 by Mdivi-1 attenuates cerebral ischemic injury via inhibition of the mitochondria-dependent apoptotic pathway after cardiac arrest

Y Li, P Wang, J Wei, R Fan, Y Zuo, M Shi, H Wu… - Neuroscience, 2015 - Elsevier
Mitochondrial fission is predominantly controlled by the activity of dynamin-related protein1
(Drp1), which has been reported to be involved in mitochondria apoptosis pathways …

SIRT4 suppresses doxorubicin-induced cardiotoxicity by regulating the AKT/mTOR/autophagy pathway

L He, J Wang, Y Yang, P Zou, Z Xia, J Li - Toxicology, 2022 - Elsevier
Doxorubicin (DOX) is a potent anthracycline chemotherapeutic drug. DOX-induced
cardiotoxicity (DIC) limits its application in cancer treatment, as this complication is …

Methamphetamine induces endoplasmic reticulum stress related gene CHOP/Gadd153/ddit3 in dopaminergic cells

Y Irie, M Saeki, H Tanaka, Y Kanemura, S Otake… - Cell and tissue …, 2011 - Springer
We examined the toxicity of methamphetamine and dopamine in CATH. a cells, which were
derived from mouse dopamine-producing neural cells in the central nervous system. Use of …