DNA damage-inducible transcript 4 (DDIT4) mediates methamphetamine-induced autophagy and apoptosis through mTOR signaling pathway in cardiomyocytes
Methamphetamine (METH) is an amphetamine-like psychostimulant that is commonly
abused. Previous studies have shown that METH can induce damages to the nervous …
abused. Previous studies have shown that METH can induce damages to the nervous …
Effects of DDIT4 in methamphetamine-induced autophagy and apoptosis in dopaminergic neurons
B Li, R Chen, L Chen, P Qiu, X Ai, E Huang… - Molecular …, 2017 - Springer
Methamphetamine (METH) is an illicit psychoactive drug that can cause a variety of
detrimental effects to the nervous system, especially dopaminergic pathways. We …
detrimental effects to the nervous system, especially dopaminergic pathways. We …
Involvement of C/EBPβ-related signaling pathway in methamphetamine-induced neuronal autophagy and apoptosis
E Huang, H Huang, T Guan, C Liu, D Qu, Y Xu, J Yang… - Toxicology Letters, 2019 - Elsevier
Methamphetamine (METH) is a widely abused illicit psychoactive drug. Our previous study
has shown that CCAAT-enhancer binding protein β (C/EBPβ) is an important regulator in …
has shown that CCAAT-enhancer binding protein β (C/EBPβ) is an important regulator in …
DDiT4L promotes autophagy and inhibits pathological cardiac hypertrophy in response to stress
Physiological cardiac hypertrophy, in response to stimuli such as exercise, is considered
adaptive and beneficial. In contrast, pathological cardiac hypertrophy that arises in response …
adaptive and beneficial. In contrast, pathological cardiac hypertrophy that arises in response …
Dexmedetomidine protects against lidocaine-induced neurotoxicity through SIRT1 downregulation-mediated activation of FOXO3a
LN Zheng, FQ Guo, ZS Li, Z Wang… - Human & …, 2020 - journals.sagepub.com
Lidocaine, a typical local anesthetic, has been shown to directly induce neurotoxicity in
clinical settings. Dexmedetomidine (DEX) is an alpha-2-adrenoreceptor agonist that has …
clinical settings. Dexmedetomidine (DEX) is an alpha-2-adrenoreceptor agonist that has …
CDK5-mediated tau accumulation triggers methamphetamine-induced neuronal apoptosis via endoplasmic reticulum-associated degradation pathway
N Xiao, F Zhang, B Zhu, C Liu, Z Lin, H Wang, WB Xie - Toxicology letters, 2018 - Elsevier
Overexposure to methamphetamine (METH) causes apoptosis in a number of cell types,
particularly neuronal cells. However, the underlying mechanisms of METH-induced …
particularly neuronal cells. However, the underlying mechanisms of METH-induced …
Knockdown of Mtfp1 can minimize doxorubicin cardiotoxicity by inhibiting Dnm1l‐mediated mitochondrial fission
LHH Aung, R Li, BS Prabhakar… - Journal of cellular and …, 2017 - Wiley Online Library
The long‐term usage of doxorubicin (DOX) is largely limited due to the development of
severe cardiomyopathy. Many studies indicate that DOX‐induced cardiac injury is related to …
severe cardiomyopathy. Many studies indicate that DOX‐induced cardiac injury is related to …
Inhibition of Drp1 by Mdivi-1 attenuates cerebral ischemic injury via inhibition of the mitochondria-dependent apoptotic pathway after cardiac arrest
Mitochondrial fission is predominantly controlled by the activity of dynamin-related protein1
(Drp1), which has been reported to be involved in mitochondria apoptosis pathways …
(Drp1), which has been reported to be involved in mitochondria apoptosis pathways …
SIRT4 suppresses doxorubicin-induced cardiotoxicity by regulating the AKT/mTOR/autophagy pathway
L He, J Wang, Y Yang, P Zou, Z Xia, J Li - Toxicology, 2022 - Elsevier
Doxorubicin (DOX) is a potent anthracycline chemotherapeutic drug. DOX-induced
cardiotoxicity (DIC) limits its application in cancer treatment, as this complication is …
cardiotoxicity (DIC) limits its application in cancer treatment, as this complication is …
Methamphetamine induces endoplasmic reticulum stress related gene CHOP/Gadd153/ddit3 in dopaminergic cells
Y Irie, M Saeki, H Tanaka, Y Kanemura, S Otake… - Cell and tissue …, 2011 - Springer
We examined the toxicity of methamphetamine and dopamine in CATH. a cells, which were
derived from mouse dopamine-producing neural cells in the central nervous system. Use of …
derived from mouse dopamine-producing neural cells in the central nervous system. Use of …