The transport of amino acids across the plasma membrane is a process of fundamental
physiological importance. If this process is modified by estrogens and if estrogen receptors …

Purpose The aim of the study is to suppress the progress of estrogen-dependent breast
cancer by inhibiting the membrane transporter, which mediates the internalization of estrone …

Objective: Our purpose was to investigate the influence of ethanol on system A amino acid
transporter in BeWo cells. Study Design: BeWo cells were cultured in the absence or …

Increased activity of amino acid transporters has been observed in a wide variety of cancers.
However, whether amino acid metabolism is related to estrogen receptor-positive (ER+) …

Estrone-3-sulfate is one of the most abundant estrogen precursors in postmenopausal
women. We previously showed that estrone-3-sulfate transporters are present in human …

Two-thirds of newly diagnosed hormone-dependent (HR+) breast cancers are detected in
post-menopausal patients where estrone-3-sulphate (E3S) is the predominant source for …

The relationship between estrogen and some types of breast cancer has been clearly
established. However, although several studies have demonstrated the relationship …

The effects of estrogens on transport and incorporation of amino acids into the R3230AC
mammary adenocarcinoma were studied in vivo and in vitro. Dissociated tumor cells from …

Approximately 70% cases of breast cancers exhibit high expression and activity levels of
estrogen receptor alpha (ERα), a transcription regulator that induces the expression of …

The current study investigates the potential of estrone-3-sulphate (E3S) as a ligand for
targeting Organic Anion Transporting Polypeptides (OATP), a family of membrane …